植物化学物质重塑白色脂肪组织微环境，对抗肥胖症。

IF 6.1 2区医学 Q1 CHEMISTRY, MEDICINAL

Phytotherapy Research Pub Date : 2024-10-01 Epub Date: 2023-02-14 DOI:10.1002/ptr.7758

Shuwei Ke, Qingyuan Hu, Guanyao Zhu, Linghuan Li, Xuechao Sun, Hongbin Cheng, Lingqiao Li, Yuanfa Yao, Hanbing Li

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引用次数: 0

摘要

肥胖症是由于能量摄入与消耗长期失衡而导致的一种慢性疾病。近年来，全球肥胖人数激增，肥胖问题不容小觑。肥胖的特征是脂肪微环境的变化，主要表现为肥厚、慢性炎症状态、缺氧和纤维化，从而导致其他组织的病理变化。研究发现，大量植物化学物质可改善脂肪微环境，从而预防和抵抗肥胖，为治疗肥胖及相关疾病提供了新的研究方向。本文探讨了重塑脂肪组织微环境的治疗途径，并回顾了植物化学物质通过改善脂肪组织微环境来对抗肥胖的研究进展。

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Remodeling of white adipose tissue microenvironment against obesity by phytochemicals.

Obesity is a kind of chronic disease due to a long-term imbalance between energy intake and expenditure. In recent years, the number of obese people around the world has soared, and obesity problem should not be underestimated. Obesity is characterized by changes in the adipose microenvironment, mainly manifested as hypertrophy, chronic inflammatory status, hypoxia, and fibrosis, thus contributing to the pathological changes of other tissues. A plethora of phytochemicals have been found to improve adipose microenvironment, thus prevent and resist obesity, providing a new research direction for the treatment of obesity and related diseases. This paper discusses remodeling of the adipose tissue microenvironment as a therapeutic avenue and reviews the progress of phytochemicals in fighting obesity by improving the adipose microenvironment.

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来源期刊

Phytotherapy Research 医学-药学

CiteScore

12.80

自引率

5.60%

发文量

325

审稿时长

2.6 months

期刊介绍： Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.