DEK:：头颈部AFF2融合癌。

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2023-03-01 Epub Date: 2022-10-12 DOI:10.1097/PAP.0000000000000376

Komkrit Ruangritchankul, Ann Sandison

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引用次数: 4

摘要

一种新的DEK:：AFF2融合癌最近在29名患者中被描述，这些患者最初表现为非病毒相关的非角化鳞状细胞癌。肿瘤发生在头颈部的多个部位，包括鼻腔、中耳和颞骨。该肿瘤表现为侵袭性侵犯邻近的重要结构，经常复发，并倾向于发展为淋巴结和远处转移。本综述旨在总结DEK:：AFF2融合癌的人口学、临床、病理、免疫表型特征和分子改变模式，并讨论其鉴别诊断。

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DEK::AFF2 Fusion Carcinomas of Head and Neck.

A novel DEK::AFF2 fusion carcinoma was recently described in 29 patients who originally presented with non-viral-associated nonkeratinizing squamous cell carcinoma. The tumors occurred at multiple sites in the head and neck including in the sinonasal tract, middle ear, and temporal bone. This tumor behaves aggressively involving adjacent vital structures, frequently recurs, and is inclined to develop lymph node and distant metastasis. This review aims to summarize the demographic, clinical, pathologic, immunophenotypic features, and pattern of molecular alterations as well as to discuss the differential diagnosis of DEK::AFF2 fusion carcinoma.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.