持续性冠状病毒后综合征(PPCS)研究进展

IF 8.4 2区 医学 Q1 ALLERGY
Bryan Oronsky, Christopher Larson, Terese C Hammond, Arnold Oronsky, Santosh Kesari, Michelle Lybeck, Tony R Reid
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引用次数: 214

摘要

持续性后冠状病毒综合征,也被称为长冠状病毒病,是一种病理实体,涉及COVID-19后持续的身体、医疗和认知后遗症,包括持续的免疫抑制以及肺、心脏和血管纤维化。器官和脉管系统的病理性纤维化导致死亡率增加和生活质量严重恶化。抑制转化生长因子β (TGF-β),一种免疫和纤维化调节剂,可能会减轻这些covid后后遗症。目前临床前和临床工作主要集中在COVID-19的发病机制和表现及其症状前和前驱期;相比之下,在COVID-19之后出现的后遗症,即我们所说的持续性COVID-19后综合征,很少受到关注。随着大量接受治疗的患者出院,COVID-19后综合征的潜在长期影响将变得越来越重要,这给医疗保健系统、患者家属和整个社会带来了照顾这些在医学上遭受重创的COVID-19幸存者的负担。本文探讨了持续covid - 19后综合征的潜在机制和可能表现,并提出了疑似或确诊持续covid - 19后综合征患者的诊断和治疗策略框架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Review of Persistent Post-COVID Syndrome (PPCS).

A Review of Persistent Post-COVID Syndrome (PPCS).

A Review of Persistent Post-COVID Syndrome (PPCS).

A Review of Persistent Post-COVID Syndrome (PPCS).

Persistent post-COVID syndrome, also referred to as long COVID, is a pathologic entity, which involves persistent physical, medical, and cognitive sequelae following COVID-19, including persistent immunosuppression as well as pulmonary, cardiac, and vascular fibrosis. Pathologic fibrosis of organs and vasculature leads to increased mortality and severely worsened quality of life. Inhibiting transforming growth factor beta (TGF-β), an immuno- and a fibrosis modulator, may attenuate these post-COVID sequelae. Current preclinical and clinical efforts are centered on the mechanisms and manifestations of COVID-19 and its presymptomatic and prodromal periods; by comparison, the postdrome, which occurs in the aftermath of COVID-19, which we refer to as persistent post-COVID-syndrome, has received little attention. Potential long-term effects from post-COVID syndrome will assume increasing importance as a surge of treated patients are discharged from the hospital, placing a burden on healthcare systems, patients' families, and society in general to care for these medically devastated COVID-19 survivors. This review explores underlying mechanisms and possible manifestations of persistent post-COVID syndrome, and presents a framework of strategies for the diagnosis and management of patients with suspected or confirmed persistent post-COVID syndrome.

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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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