限制热量以治疗恶性肿瘤--从动物研究到临床转化。

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Aggelos T Margetis
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引用次数: 0

摘要

过去几年中,大量研究表明,以限制热量为形式的膳食调整对衰老相关病症、自身免疫性疾病和癌症等几种临床实体产生了有益的影响。作为预防和治疗方法,这些饮食方案可影响全身代谢、免疫和荷尔蒙反应、氧化还原平衡和肠道微生物群等。在肿瘤学领域,绝大多数实验工作都探讨了限制性饮食在预防恶性肿瘤中的作用,主要是在致癌诱导模型中,至少取得了令人鼓舞的结果;相反,在利用生酮饮食或热量限制方案治疗全面性癌症方面的研究较少。在此,我们旨在回顾迄今为止研究热量限制在治疗已确诊癌症中作用的相关临床前和临床研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Caloric restriction for the management of malignant tumors - from animal studies towards clinical translation.

In the last few years, numerous studies have demonstrated that dietary modifications in the form of calory restriction exert beneficial effects in several clinical entities, including aging-related pathologies, autoimmune diseases and cancer. Both as preventive but also as therapeutic modalities, these dietary regimens can impact systemic metabolism, immune and hormonal responses, redox balance and gut microbiota, among others. In the field of oncology, the vast majority of experimental work has explored the role of restricted diets in the prevention of malignant tumors, mostly in carcinogenesis-induced models, with at least encouraging results; on the contrary, less research has been performed in the management of full-blown cancer with ketogenic diet or caloric restriction protocols. Herein, we are aiming to review the relevant preclinical and clinical studies to date that investigate the role of caloric restriction in the treatment of established cancer.

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来源期刊
CiteScore
5.00
自引率
4.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds. The editorial and advisory boards include many of the leading persons currently working in this area. The journal is of particular interest to: - Nutritionists - Vitaminologists - Biochemists - Physicians - Engineers of human and animal nutrition - Food scientists
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