原发性醛固酮增多症和矿物质皮质激素受体拮抗剂对心脏和肾脏的作用。

IF 15.1 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Annual review of medicine Pub Date : 2023-01-27 Epub Date: 2022-11-14 DOI:10.1146/annurev-med-042921-100438
Jordana B Cohen, Irina Bancos, Jenifer M Brown, Harini Sarathy, Adina F Turcu, Debbie L Cohen
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引用次数: 0

摘要

原发性醛固酮增多症(PA)是继发性高血压最常见的原因,但经常被低估和治疗不足。PA患者心脏和肾脏靶器官损伤的风险显著增加。虽然单侧PA患者可以通过手术治疗,但许多PA患者不符合或不愿意接受手术。类固醇盐皮质激素受体拮抗剂(MRAs)在治疗PA和降低靶器官损伤风险方面非常有效。然而,甾体MRA通常处方不足,并且由于副作用,一些患者的耐受性较差。非甾体类药物可降低糖尿病肾病患者的不良肾脏和心血管后果,并且比甾体类药耐受性更好。虽然它们的降压作用尚不清楚,但这些药物可能在减少PA患者靶器官损伤方面发挥潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Primary Aldosteronism and the Role of Mineralocorticoid Receptor Antagonists for the Heart and Kidneys.

Primary aldosteronism (PA) is the most common cause of secondary hypertension but is frequently underrecognized and undertreated. Patients with PA are at a markedly increased risk for target organ damage to the heart and kidneys. While patients with unilateral PA can be treated surgically, many patients with PA are not eligible or willing to undergo surgery. Steroidal mineralocorticoid receptor antagonists (MRAs) are highly effective for treating PA and reducing the risk of target organ damage. However, steroidal MRAs are often underprescribed and can be poorly tolerated by some patients due to side effects. Nonsteroidal MRAs reduce adverse renal and cardiovascular outcomes among patients with diabetic kidney disease and are bettertolerated than steroidal MRAs. While their blood pressure-lowering effects remain unclear, these agents may have a potential role in reducing target organ damage in patients with PA.

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来源期刊
Annual review of medicine
Annual review of medicine 医学-医学:内科
CiteScore
24.90
自引率
0.00%
发文量
58
期刊介绍: The Annual Review of Medicine, which has been published since 1950, focuses on important advancements in diverse areas of medicine. These include AIDS/HIV, cardiology, clinical pharmacology, dermatology, endocrinology/metabolism, gastroenterology, genetics, immunology, infectious disease, neurology, oncology/hematology, pediatrics, psychiatry, pulmonology, reproductive medicine, and surgery. The journal's current volume has transitioned from a gated access model to an open access model through the Annual Reviews' Subscribe to Open program. All articles published in the journal are now available under a CC BY license.
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