natalizumab对多发性硬化症患者静息状态连通性的影响。

IF 2.6 Q2 CLINICAL NEUROLOGY
Diogo G Corrêa, Eelco van Duinkerken, João Gabriel D Farinhas, Valéria C Pereira, Emerson L Gasparetto, Soniza V Alves-Leon, Fernanda Cristina R Lopes
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引用次数: 0

摘要

背景:多发性硬化症(MS)患者的大脑连通性发生变化,即使在接受疾病改善治疗的患者中也是如此。使用磁共振成像(MRI)来评估接受疾病改善疗法(如natalizumab)治疗的患者,可以阐明MS临床恶化的机制。目的:评估接受natalizumab治疗的MS患者、未接受natalizumab治疗的MS患者和对照组静息状态功能连通性的差异。设计:单中心回顾性横断面研究。方法:回顾性比较23例接受纳他珠单抗治疗的MS患者与23例接受纳他珠单抗naïve治疗并使用一线药物(干扰素-β和/或醋酸格拉替雷)的MS患者,以及17例性别和年龄匹配的对照组。MS患者组也匹配自诊断以来的时间和FLAIR上的高病变体积。所有参与者都使用3特斯拉扫描仪进行了脑部核磁共振成像。利用FMRIB软件库,采用独立成分分析和双回归方法鉴定静息状态功能连通性。结果:与对照组相比,接受natalizumab治疗的MS患者左侧眶额皮质、前扣带和眶额皮质网络的连通性下降。与对照组相比,未接受natalizumab治疗的患者在次要视觉、感觉运动和腹侧注意网络中表现出增加的连通性。与接受纳他珠单抗治疗的患者相比,未使用纳他珠单抗的患者在腹侧注意网络中左侧颞回和右侧额上回的连连性增加。结论:未接受纳他珠单抗治疗的MS患者、健康对照者和接受纳他珠单抗治疗的患者之间脑连通性的差异可能继发于先前治疗效率较低的次优神经元代偿,或由于对适应不良可塑性的补偿。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Influence of natalizumab on resting-state connectivity in patients with multiple sclerosis.

Influence of natalizumab on resting-state connectivity in patients with multiple sclerosis.

Influence of natalizumab on resting-state connectivity in patients with multiple sclerosis.

Influence of natalizumab on resting-state connectivity in patients with multiple sclerosis.

Background: Changes in brain connectivity occur in patients with multiple sclerosis (MS), even in patients under disease-modifying therapies. Using magnetic resonance imaging (MRI) to asses patients treated with disease-modifying therapies, such as natalizumab, can elucidate the mechanisms involved in clinical deterioration in MS.

Objectives: To evaluate differences in resting-state functional connectivity among MS patients treated with natalizumab, MS patients not treated with natalizumab, and controls.

Design: Single-center retrospective cross-sectional study.

Methods: Twenty-three MS patients being treated with natalizumab were retrospectively compared with 23 MS patients who were naïve for natalizumab, and were using first-line medications (interferon-β and/or glatiramer acetate), and 17 gender- and age-matched control subjects. The MS patient groups were also matched for time since diagnosis and hyperintense lesion volume on FLAIR. All participants underwent brain MRI using a 3 Tesla scanner. Independent component analysis and dual regression were used to identify resting-state functional connectivity using the FMRIB Software Library.

Results: In comparison to controls, the MS patients treated with natalizumab presented decreased connectivity in the left orbitofrontal cortex, in the anterior cingulate and orbitofrontal cortex network. The patients not treated with natalizumab presented increased connectivity in the secondary visual, sensorimotor, and ventral attention networks in comparison to controls.Compared to patients treated with natalizumab, the patients not using natalizumab presented increased connectivity in the left Heschl's gyrus and in the right superior frontal gyrus in the ventral attention network.

Conclusion: Differences in brain connectivity between MS patients not treated with natalizumab, healthy controls, and patients treated with natalizumab may be secondary to suboptimal neuronal compensation due to prior less efficient treatments, or due to a compensation in response to maladaptive plasticity.

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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
39
审稿时长
8 weeks
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