有望成为治疗高原疾病的天然药物。

IF 1.6 4区 医学 Q4 BIOPHYSICS
High altitude medicine & biology Pub Date : 2023-09-01 Epub Date: 2023-07-27 DOI:10.1089/ham.2022.0139
Li Li, Lin Lin, Bo Wen, Peng-Cheng Zhao, Da-Sheng Liu, Guo-Ming Pang, Zi-Rong Wang, Yong Tan, Cheng Lu
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引用次数: 0

摘要

李丽、林琳、Bo温、赵、刘大生、庞国明、王子荣、谭勇、陆。治疗高原疾病的天然药物。High Alt-Med Biol.24:175-1852023。-高原疾病(HAI)是一种危险的疾病,其特征是身体中的氧化应激、炎症损伤和血液动力学变化,可能导致肺部、心脏和大脑的严重损伤。天然药物以其多种活性成分和药理作用而广为人知,这可能在治疗HAI方面具有重要意义。在这篇综述中,我们概述了HAI的具体类型和潜在的病理机制,并总结了目前有文献记载的用于治疗急性山地病和高空脑水肿、高空肺水肿、慢性山地病和高海拔肺动脉高压的天然药物。综述了它们的来源、类型和药用部位,并讨论了它们的活性成分、药理作用、相关机制和潜在毒性。总之,天然药物作为一种可接受的补充和替代策略,具有较少的副作用和更长期的应用,可以为未来开发更多的天然抗晕药物提供参考,并在HAI治疗中具有良好的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Promising Natural Medicines for the Treatment of High-Altitude Illness.

Promising Natural Medicines for the Treatment of High-Altitude Illness.

Promising Natural Medicines for the Treatment of High-Altitude Illness.

Promising Natural Medicines for the Treatment of High-Altitude Illness.

Li Li, Lin Lin, Bo Wen, Peng-cheng Zhao, Da-sheng Liu, Guo-ming Pang, Zi-rong Wang, Yong Tan, and Cheng Lu. Promising natural medicines for the treatment of high-altitude illness. High Alt Med Biol. 24:175-185, 2023.-High-altitude illness (HAI) is a dangerous disease characterized by oxidative stress, inflammatory damage and hemodynamic changes in the body that can lead to severe damage to the lungs, heart, and brain. Natural medicines are widely known for their multiple active ingredients and pharmacological effects, which may be important in the treatment of HAI. In this review, we outline the specific types of HAI and the underlying pathological mechanisms and summarize the currently documented natural medicines applied in the treatment of acute mountain sickness and high-altitude cerebral edema, high-altitude pulmonary edema, chronic mountain sickness, and high-altitude pulmonary hypertension. Their sources, types, and medicinal sites are summarized, and their active ingredients, pharmacological effects, related mechanisms, and potential toxicity are discussed. In conclusion, natural medicines, as an acceptable complementary and alternative strategy with fewer side effects and more long-term application, can provide a reference for developing more natural antialtitude sickness medicines in the future and have good application prospects in HAI treatment.

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来源期刊
High altitude medicine & biology
High altitude medicine & biology 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.80
自引率
9.50%
发文量
44
审稿时长
>12 weeks
期刊介绍: High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.
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