大麻二酚在肺癌中的抗肿瘤作用:到目前为止我们知道什么?-迷你评论

Q2 Biochemistry, Genetics and Molecular Biology
Vasileio Issaris, Gerasimos Panagiotis Milas, Nicholas Zareifopoulos
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引用次数: 1

摘要

肺癌仍然是世界范围内造成发病率和死亡率的一个主要因素。大麻二酚(cannabidiol, CBD)和Δ9-tetrahydrocannabinol在肺癌细胞凋亡中起重要作用,可作为肺癌的特异性治疗药物。本文综述了CBD在肺癌细胞中的抗肿瘤机制。我们搜索了MEDLINE、clinicaltrials.gov、Cochrane Central Register of Controlled Trials和Google Scholar等数据库。在筛选的246项研究中,有9项纳入并使用ToxRTool进行评估。所有选择的研究都是在体外进行的,其中四项研究也有体内含量。所有研究中最常用的细胞系是A549;然而,一些研究包含了其他细胞系,包括H460和H358。我们的研究结果表明,CBD通过大麻素受体介导或独立于大麻素受体的多种机制对肺癌细胞具有直接的抗肿瘤作用。所有研究均参照体外模型;因此,需要在动物身上进行进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Antitumorigenic Effect of Cannabidiol in Lung Cancer: What Do We Know So Far?–A Mini Review

Antitumorigenic Effect of Cannabidiol in Lung Cancer: What Do We Know So Far?–A Mini Review

Lung cancer remains a major factor contributing to morbidity and mortality worldwide. cannabidiol (CBD) and Δ9-tetrahydrocannabinol could serve as a specific treatment for lung cancer, owing to their essential role in lung cancer cell apoptosis. This review evaluated the antitumorigenic mechanisms of CBD in lung cancer cells. We searched the databases MEDLINE, clinicaltrials.gov, Cochrane Central Register of Controlled Trials, and Google Scholar using specific terms. Of 246 studies screened, nine were included and assessed using the ToxRTool. All the selected studies were conducted in vitro, and four of which also had an in vivo content. The most common cell line used in all the studies was A549; however, some studies contained other cell lines, including H460 and H358. Our findings suggested that CBD has direct antineoplastic effects on lung cancer cells through various mechanisms mediated by cannabinoid receptors or independent of these receptors. All studies were referred to an in vitro model; hence, further research in animals is required.

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来源期刊
Iranian Biomedical Journal
Iranian Biomedical Journal Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
3.20
自引率
0.00%
发文量
42
审稿时长
8 weeks
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