治疗 COVID-19。

IF 15.1 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Annual review of medicine Pub Date : 2024-01-29 Epub Date: 2023-09-18 DOI:10.1146/annurev-med-052422-020316
Hayden S Andrews, Jonathan D Herman, Rajesh T Gandhi
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引用次数: 0

摘要

COVID-19 的治疗方法自大流行开始以来发展迅速,目前主要包括抗病毒和免疫调节药物。事实证明,抗病毒药物,如雷米替韦和尼马替韦-利托那韦,在发病初期(如作为门诊治疗)和病情较轻时最有用。免疫调节疗法,如地塞米松和白细胞介素-6 或 Janus 激酶抑制剂,对重症或危重病人最有用。抗 SARS-CoV-2 单克隆抗体的作用已经减弱,因为出现了预计对这些疗法不敏感的病毒变种,而且在使用康复血浆方面仍未达成共识。COVID-19 与静脉血栓栓塞率升高有关,但抗血栓治疗的作用有限。多种研究药物仍在研究中,随着新数据的发布,这些药物将改变目前的治疗模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatments for COVID-19.

The treatment for COVID-19 has evolved rapidly since the start of the pandemic and now consists mainly of antiviral and immunomodulatory agents. Antivirals, such as remdesivir and nirmatrelvir-ritonavir, have proved to be most useful earlier in illness (e.g., as outpatient therapy) and for less severe disease. Immunomodulatory therapies, such as dexamethasone and interleukin-6 or Janus kinase inhibitors, are most useful in severe disease or critical illness. The role of anti-SARS-CoV-2 monoclonal antibodies has diminished because of the emergence of viral variants that are not anticipated to be susceptible to these treatments, and there still is not a consensus on the use of convalescent plasma. COVID-19 has been associated with increased rates of venous thromboembolism, but the role of antithrombotic therapy is limited. Multiple investigational agents continue to be studied, which will alter current treatment paradigms as new data are released.

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来源期刊
Annual review of medicine
Annual review of medicine 医学-医学:内科
CiteScore
24.90
自引率
0.00%
发文量
58
期刊介绍: The Annual Review of Medicine, which has been published since 1950, focuses on important advancements in diverse areas of medicine. These include AIDS/HIV, cardiology, clinical pharmacology, dermatology, endocrinology/metabolism, gastroenterology, genetics, immunology, infectious disease, neurology, oncology/hematology, pediatrics, psychiatry, pulmonology, reproductive medicine, and surgery. The journal's current volume has transitioned from a gated access model to an open access model through the Annual Reviews' Subscribe to Open program. All articles published in the journal are now available under a CC BY license.
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