与奥萨拉嗪交联的可快速降解魔芋葡甘露聚糖水凝胶用于结肠药物释放。

IF 1 4区医学 Q4 ENGINEERING, BIOMEDICAL

Bio-medical materials and engineering Pub Date : 2024-01-01 DOI:10.3233/BME-230066

Qiao Zhang, Huili Fu, Yunfei Zhang, Liang Li, Guoping Yan

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引用次数: 0

摘要

背景：多糖水凝胶是结肠靶向药物释放系统最重要的材料之一。然而，多糖水凝胶的降解时间远远长于药物在结肠中的滞留时间。因此，药物在释放前会被排出体外：为了使药物载体的降解和在结肠中的保留时间相匹配，我们设计了一种可快速降解的魔芋葡甘露聚糖（KGM）水凝胶，用于结肠靶向药物释放：方法：使用含偶氮键的交联剂奥萨拉嗪制备可快速降解的魔芋葡甘露聚糖（KGM）水凝胶。研究了不同交联密度的水凝胶在正常缓冲液和人体粪便培养基中的降解和药物释放情况，以评估结肠药物释放的效率：以重量计，超过50%的KGM水凝胶在5% w/v的人类粪便培养基中降解，超过60%的5-氟尿嘧啶（5-Fu）在48小时内释放：结论：与普通缓冲液相比，药物在模拟结肠环境中的释放速度更快。此外，药物的释放受水凝胶降解的控制。含有偶氮交联剂的 KGM 水凝胶在结肠药物释放方面具有很大的潜力。

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Rapidly degradable konjac glucomannan hydrogels cross-linked with olsalazine for colonic drug release.

Background: Polysaccharide hydrogel is one of the most important materials for the colon target drug release system. However, the degradation time of polysaccharide hydrogel is much longer than the retention time in the colon. The drugs are expelled from the body before being released.

Objective: In order to match the degradation of drug carriers and their retention time in the colon, a rapidly degradable konjac glucomannan (KGM) hydrogel was designed for colon target drug release.

Methods: A crosslinker containing azo bond, olsalazine, was used to prepare the rapidly degradable KGM hydrogel. The degradation and drug release of the hydrogels with different crosslinking densities in the normal buffer and the human fecal medium were studied to evaluate the efficiency of colon drug release.

Results: More than 50% of the KGM hydrogel by weight was degraded and more than 60% of the 5-fluorouracil (5-Fu) was released within 48 h in 5% w/v human fecal medium.

Conclusion: The drug was released more rapidly in a simulated colon environment than in a normal buffer. Furthermore, the drug release was controlled by the degradation of the hydrogel. The KGM hydrogel containing azo crosslinker has great potential for colon drug release.

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来源期刊

Bio-medical materials and engineering 工程技术-材料科学：生物材料

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.