母体高血压与早期发病的新生儿中性粒细胞减少症。

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2023-10-01 Epub Date: 2023-06-05 DOI:10.1080/15513815.2023.2220406

Peter Joslyn, Evrim Oral, Anne Martin, Jeffrey Surcouf, Brian Barkemeyer

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引用次数: 0

摘要

目的：母亲高血压被认为是早期新生儿中性粒细胞减少症的危险因素。我们试图探索这种关系。研究设计：这项回顾性队列研究使用负二项回归（NBR）和逻辑回归模型比较了患有重度子痫前期（PSF）的母亲所生婴儿和血压正常的母亲所产婴儿的初始中性粒细胞计数。结果：母亲高血压对早期新生儿中性粒细胞计数产生负面影响（调整后的NRB系数为0.4[0.2，0.6]，p p = 0.06）。PSF亚组之间的初始中性粒细胞计数和中性粒细胞减少风险没有差异。妊娠年龄对中性粒细胞减少症风险的影响最大（OR 0.72[0.64，0.81]，p 结论：母体高血压对新生儿早期中性粒细胞计数有负面影响，但不会增加新生儿中性粒细胞减少症的风险。

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Maternal Hypertension and Early-Onset Neonatal Neutropenia.

Objective: Maternal hypertension is considered a risk factor for early neonatal neutropenia. We sought to explore this relationship. Study Design: This retrospective cohort study compared initial neutrophil counts in infants born to mothers with preeclampsia with severe features (PSF) and infants born to normotensive mothers using Negative Binomial Regression (NBR) and logistic regression models. Results: Maternal hypertension negatively affected the early neonatal neutrophil count (adjusted NRB coefficient 0.4 [0.2, 0.6], p < 0.0001) but did not increase the risk of neutropenia (OR 2.07 [0.97, 4.41], p = 0.06). The initial neutrophil count and neutropenia risk were not different between PSF subgroups. Gestational age had the greatest impact on neutropenia risk (OR 0.72 [0.64, 0.81], p < 0.0001). Almost all neutropenia resolved within 48 h. Conclusion: Maternal hypertension negatively affects the early neonatal neutrophil count while not increasing the risk of neonatal neutropenia.

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.