智力和发育障碍不同病因亚群的独特疼痛反应。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-09-01 DOI:10.1352/1944-7558-127.5.417

Ruth Defrin, Tali Benromano, Chaim G Pick

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引用次数: 0

摘要

我们研究了不同的智力和发育障碍(IDD)病因是否存在疼痛反应的差异。在实验压力刺激时记录自我报告和面部表情(面部动作编码系统= FACS)，并比较31名IDD-13脑瘫(CP)患者、9名唐氏综合征(DS)患者、9名不明原因(UIDD)患者和15名典型发展对照(tdc)患者。与UIDD和TDC组相比，CP组和DS组的疼痛评分和FACS评分更高，刺激反应函数更陡。DS组表现出最多样化的面部表情。两组之间的面部表情焦点存在差异。似乎不同的IDD病因表现出不同的疼痛反应。

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Unique Pain Responses in Different Etiological Subgroups of Intellectual and Developmental Disabilities.

We studied whether there exist variations in pain responses between different intellectual and developmental disability (IDD) etiologies. Self-reports and facial expressions (Facial Action Coding System = FACS) were recorded during experimental pressure stimuli and compared among 31 individuals with IDD-13 with cerebral palsy (CP), nine with Down syndrome (DS), nine with unspecified origin (UIDD)-and among 15 typically developing controls (TDCs). The CP and DS groups had higher pain ratings and FACS scores compared to the UIDD and TDC groups, and steeper stimulus-response functions. The DS group exhibited the most diverse facial expressions. There were variations in the foci of facial expressions between groups. It appears that different IDD etiologies display distinct pain responses.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.