解析药理学:重点关注促进炎症治疗创新的促溶解附件蛋白 A1 和脂质介质。

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Mauro Perretti, Jesmond Dalli
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引用次数: 0

摘要

影响我们社会的慢性疾病因合并症而变得更加复杂,而且目前的药物治疗效果不佳。虽然所有这些疾病的病因都是炎症,但更好地临床治疗这些疾病及其多种症状的需求仍未得到满足。我们在此讨论一种基于炎症消解生物学的创新方法。研究内源性促消炎肽和脂质介质、它们是如何形成的,以及它们与哪个靶点相互作用,可以通过增强促消炎途径的表达或功能,或用新型靶向分子模拟它们的作用,提供创新选择。在所有情况下,溶解药理学都能为治疗特定疾病的主要病因和/或控制其并发症提供创新方案,最终改善患者的生活质量。通过解析药理学,我们可以利用炎症的整个生理学过程,从而有可能显著改变炎症的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation.

Chronic diseases that affect our society are made more complex by comorbidities and are poorly managed by the current pharmacology. While all present inflammatory etiopathogeneses, there is an unmet need for better clinical management of these diseases and their multiple symptoms. We discuss here an innovative approach based on the biology of the resolution of inflammation. Studying endogenous pro-resolving peptide and lipid mediators, how they are formed, and which target they interact with, can offer innovative options through augmenting the expression or function of pro-resolving pathways or mimicking their actions with novel targeted molecules. In all cases, resolution offers innovation for the treatment of the primary cause of a given disease and/or for the management of its comorbidities, ultimately improving patient quality of life. By implementing resolution pharmacology, we harness the whole physiology of inflammation, with the potential to bring a marked change in the management of inflammatory conditions.

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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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