触觉刺激可改善成年APPNL-G-F/NL-G-F小鼠的认知、运动和焦虑样行为，并减轻阿尔茨海默病病理。

IF 1.6 4区医学 Q4 NEUROSCIENCES

Synapse Pub Date : 2023-03-01 DOI:10.1002/syn.22257

Shakhawat R Hossain, Hadil Karem, Zahra Jafari, Bryan E Kolb, Majid H Mohajerani

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引用次数: 1

摘要

阿尔茨海默病(AD)是世界上最大的健康危机之一。然而，治疗阿尔茨海默病的药物干预有限，而且大多数治疗选择不是为了治愈或预防，而是为了减缓疾病的进展。本研究旨在探讨触觉刺激(TS)对AD小鼠模型APPNL-G-F/NL-G-F小鼠AD样症状和病理的影响。结果表明，TS在认知、运动和焦虑样行为测试中减轻了AD样症状，这些行为的改善与APP小鼠AD病理减少有关。因此，TS似乎是一种很有前途的非侵入性策略，可以减缓老年动物痴呆的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tactile stimulation improves cognition, motor, and anxiety-like behaviors and attenuates the Alzheimer's disease pathology in adult APP^{NL-G-F/NL-G-F} mice.

Alzheimer's disease (AD) is one of the largest health crises in the world. There are limited pharmaceutical interventions to treat AD, however, and most of the treatment options are not for cure or prevention, but rather to slow down the progression of the disease. The aim of this study was to examine the effect of tactile stimulation (TS) on AD-like symptoms and pathology in APP^{NL-G-F/NL-G-F} mice, a mouse model of AD. The results show that TS reduces the AD-like symptoms on tests of cognition, motor, and anxiety-like behaviors and these improvements in behavior are associated with reduced AD pathology in APP mice. Thus, TS appears to be a promising noninvasive strategy for slowing the onset of dementia in aging animals.

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来源期刊

Synapse 医学-神经科学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： SYNAPSE publishes articles concerned with all aspects of synaptic structure and function. This includes neurotransmitters, neuropeptides, neuromodulators, receptors, gap junctions, metabolism, plasticity, circuitry, mathematical modeling, ion channels, patch recording, single unit recording, development, behavior, pathology, toxicology, etc.