终末期肾病中的肾细胞癌:匈牙利患者的回顾性研究。

IF 3.5 4区 医学 Q3 CELL BIOLOGY
Pathobiology Pub Date : 2023-01-01 Epub Date: 2023-01-25 DOI:10.1159/000529276
Dávid Semjén, Borbála Dénes, Áron Somorácz, Attila Fintha, Gertrúd Forika, Alex Jenei, Deján Dobi, Tamás Micsik, Kornélia Veronika Eizler, Nándor Giba, Fanni Sánta, Anita Sejben, Béla Iványi, Levente Kuthi
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引用次数: 1

摘要

引言:终末期肾病(ESRD)和获得性囊性肾病(ACKD)是肾细胞癌(RCC)的已知危险因素。在此基础上,对ESRD中RCCs的临床病理特征进行了研究。方法:在2566例肾细胞癌肾切除术样本中,建立了一个由31例ESRD患者的34个肿瘤组成的数据库。对人口统计学、临床和随访数据以及病理学参数进行分析。RCCs是根据世界卫生组织目前的泌尿系和男性生殖器肿瘤分类诊断的。结果:22例肿瘤发生在男性,12例发生在女性,中位年龄为56岁(范围:27-75岁)。ESRD的病因为肾小球肾炎(n=7)、高血压肾病(n=6)、常染色体显性遗传的多囊肾病(n=6)、慢性肾盂肾炎(n=4)、糖尿病肾病(n=3)、化疗诱导的肾病(n=1)和未确定的肾病(n=4)。ACKD并发ESRD 12例。确定了以下组织学亚型:透明细胞RCC(n=19)、乳头状RCC(n=5)、透明细胞乳头状肿瘤(n=5。肿瘤的中位大小为31毫米(范围:10-80毫米),32个肿瘤局限于肾脏(pT1-pT2)。在本研究期间,没有肿瘤特异性死亡。1名患者出现进展。结论:在我们的队列中,最常见的RCC亚型是透明细胞RCC(55%),其频率明显超过了国际数据(14-25%)。透明细胞乳头状瘤和ACKD RCC的发病率(14.7%和8.5%)低于文献中报道的数据(30%和40%)。我们的研究结果表明ESRD患者的RCC预后良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Renal Cell Carcinoma in End-Stage Renal Disease: A Retrospective Study in Patients from Hungary.

Introduction: End-stage renal disease (ESRD) and acquired cystic kidney disease (ACKD) are known risk factors for renal cell carcinoma (RCC). Hereby, the clinicopathological features of RCCs developed in ESRD were investigated.

Methods: A database consisting of 34 tumors from 31 patients with ESRD among 2,566 nephrectomy samples of RCC was built. The demographic, clinical, and follow-up data along with pathological parameters were analyzed. The RCCs were diagnosed according to the current WHO Classification of Urinary and Male Genital Tumors.

Results: Twenty-two tumors developed in men and 12 in women, with a median age of 56 years (range: 27-75 years). The causes of ESRD were glomerulonephritis (n = 7), hypertensive kidney disease (n = 6), autosomal dominant polycystic kidney disease (n = 6), chronic pyelonephritis (n = 4), diabetic nephropathy (n = 3), chemotherapy-induced nephropathy (n = 1), and undetermined (n = 4). ACKD complicated ESRD in 12 patients. The following histological subtypes were identified: clear cell RCC (n = 19), papillary RCC (n = 5), clear cell papillary tumor (n = 5), ACKD RCC (n = 3), and eosinophilic solid and cystic RCC (n = 2). The median tumor size was 31 mm (range: 10-80 mm), and 32 tumors were confined to the kidney (pT1-pT2). There was no tumor-specific death during the period of this study. Progression was registered in 1 patient.

Conclusion: In our cohort, the most common RCC subtype was clear cell RCC (55%), with a frequency that exceeded international data appreciably (14-25%). The incidence of clear cell papillary tumor and ACKD RCC (14.7% and 8.5%) was lower than data reported in the literature (30% and 40%). Our results indicate a favorable prognosis of RCC in ESRD.

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来源期刊
Pathobiology
Pathobiology 医学-病理学
CiteScore
8.50
自引率
0.00%
发文量
47
审稿时长
>12 weeks
期刊介绍: ''Pathobiology'' offers a valuable platform for the publication of high-quality original research into the mechanisms underlying human disease. Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. Published bimonthly, ''Pathobiology'' features original research papers and reviews on translational research. The journal offers the possibility to publish proceedings of meetings dedicated to one particular topic.
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