局部干预治疗慢性伤口疼痛的系统综述。

IF 3.4 Q2 NEUROSCIENCES
Pain Reports Pub Date : 2023-09-12 eCollection Date: 2023-09-01 DOI:10.1097/PR9.0000000000001073
Cathal Ffrench, David Finn, Akke Velligna, John Ivory, Catherine Healy, Karen Butler, Duygu Sezgin, Peter Carr, Sebastian Probst, Aonghus McLoughlin, Sundus Arshad, Caroline McIntosh, Georgina Gethin
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引用次数: 1

摘要

慢性伤口会对生活质量产生不利影响。疼痛与慢性伤口有关,其影响可能因伤口病因、状况和患者因素而异。这项系统综述以随机对照试验(RCT)的PRISMA建议为指导,检查了局部干预在治疗慢性伤口相关疼痛方面的有效性,其中疼痛减轻是主要结果。纳入标准为患有慢性静脉、动脉、糖尿病或压疮的成年人(18岁以上),其疼痛通过局部施用药物/非药物来控制。检索在Ovid Embase、Ovid MEDLINE、EBSCOhost、CINAHL、CENTRAL、PubMed、Web of Science和Scopus中进行。对研究的合格性进行了筛选;偏倚风险和数据由2名独立评估员提取。搜索检索到10327篇标题和摘要(重复数据消除后为7760篇)。包括9篇全文(1323名参与者),研究布洛芬(n=4)、吗啡(n=2)、BWD+PHMB[含聚己酰胺的生物纤维素伤口敷料](n=1)和EMLA(n=2。使用Cochrane偏倚风险2工具评估偏倚风险。荟萃分析尚不可能,但初步研究表明,与对照组相比,布洛芬的疗效有所改善(疼痛减轻)。两项涉及吗啡的研究结果相互矛盾。纳入的研究通常样本较少,考虑到混杂因素(如合并症),应谨慎解释结果。对纳入研究的回顾表明,局部干预可以缓解慢性伤口患者的疼痛。建议进一步进行动力充足的随机对照试验,以评估局部干预治疗慢性伤口相关疼痛的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Systematic review of topical interventions for the management of pain in chronic wounds.

Chronic wounds adversely affect quality of life. Pain is associated with chronic wounds, and its impact can vary according to wound aetiology, condition, and patient factors. This systematic review examined the effectiveness of topical interventions in the management chronic wound-related pain guided by PRISMA recommendations of randomised controlled trials (RCTs) where pain reduction is the primary outcome. Inclusion criteria were adults (older than 18 years) with chronic venous, arterial, diabetic, or pressure ulcers where pain has been managed through topical administration of pharmacological/nonpharmacological agents. Searches were conducted in Ovid Embase, Ovid MEDLINE, EBSCOhost, CINAHL, CENTRAL, PubMed, Web of Science, and Scopus. Studies were screened for eligibility; risk of bias and data were extracted by 2 independent assessors. Searches retrieved 10,327 titles and abstracts (7760 after deduplication). Nine full texts (1323 participants) examining ibuprofen (n = 4), morphine (n = 2), BWD + PHMB [polihexanide-containing biocellulose wound dressing] (n = 1), and EMLA (n = 2) were included. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Meta-analysis was not possible, but initial exploration suggests improved outcomes (reduced pain) for ibuprofen when compared with controls. Two studies involving morphine showed conflicting findings. Included studies often had small samples, and considering confounding factors (eg, comorbidities), the results should be interpreted with caution. Review of included studies suggests that topical interventions may provide pain relief in individuals with chronic wounds. Further adequately powered RCTs are recommended to assess the efficacy of topical interventions for the management of chronic wound-related pain.

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来源期刊
Pain Reports
Pain Reports Medicine-Anesthesiology and Pain Medicine
CiteScore
7.50
自引率
2.10%
发文量
93
审稿时长
8 weeks
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