探讨供肺损伤的易感因素及发病机制。

IF 2.9 3区 医学 Q2 RESPIRATORY SYSTEM
Jing Yu, Nan Zhang, Zhiyuan Zhang, Yuping Li, Jiameng Gao, Chang Chen, Zongmei Wen
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引用次数: 0

摘要

肺移植(LTx)仍然是无法治愈的肺部疾病患者的唯一治疗策略。然而,它的使用受到供体池狭窄和供体肺质量低劣的潜在担忧的严重限制,供体肺比其他移植器官更容易受到外部影响。多种损伤,包括各种死亡原因和一系列死前事件,可能共同作用于供体肺,最终导致移植后的原发性移植物功能障碍(PGD)以及其他不良的短期结果。涵盖领域:本综述主要关注供体肺损伤的易感因素,特别是这些损伤的发病机制及其对移植后结果的影响。此外,还提出了各种减轻供体肺损伤的方法。专家意见:合格供体的选择标准各不相同,可能对肺损伤的鉴别能力较差。并非所有移植的肺都处于理想状态。随着LTx等待名单的迅速增加,使用边缘供体的趋势更加明显,这凸显了对供体肺损伤有更深入了解和发现更多供体资源的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring predisposing factors and pathogenesis contributing to injuries of donor lungs.

Introduction: Lung transplantation (LTx) remains the only therapeutic strategy for patients with incurable lung diseases. However, its use has been severely limited by the narrow donor pool and potential concerns of inferior quality of donor lungs, which are more susceptible to external influence than other transplant organs. Multiple insults, including various causes of death and a series of perimortem events, may act together on donor lungs and eventually culminate in primary graft dysfunction (PGD) after transplantation as well as other poor short-term outcomes.

Areas covered: This review focuses on the predisposing factors contributing to injuries to the donor lungs, specifically focusing on the pathogenesis of these injuries and their impact on post-transplant outcomes. Additionally, various maneuvers to mitigate donor lung injuries have been proposed.

Expert opinion: The selection criteria for eligible donors vary and may be poor discriminators of lung injury. Not all transplanted lungs are in ideal condition. With the rapidly increasing waiting list for LTx, the trend of using marginal donors has become more apparent, underscoring the need to gain a deeper understanding of donor lung injuries and discover more donor resources.

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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
90
期刊介绍: Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity
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