大脑对参与感觉运动任务的引导以诱导享乐性愉悦以减轻高血压患者的血压。

IF 1.8 Q4 NEUROSCIENCES
Madhuri Taranikanti, Aswin Kumar Mudunuru, Archana Gaur, Anzala Kauser, Sai Shriya Taranikanti, Madhusudhan Umesh, Vidya Ganji, Kalpana Medala, Roja Katta, Varatharajan Sakthivadivel, Akhila Dronamraju, Rohith Kumar Guntuka
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引用次数: 0

摘要

背景:高血压是心血管疾病的可改变危险因素,是脑卒中和冠心病导致的主要死亡原因。一些降低血压的药理学和非药理学干预措施已经尝试过了。调节大脑区域,如前额皮质(PFC)来引导活动是一种有效的目标血压的工具。目的:利用一种新的反应时间范式,探讨前额叶皮层(PFC)对交感神经兴奋回路的抑制控制。方法:选取年龄40 ~ 70岁的高血压患者,男女各30例。设计了一个结构化的反应时间范式,包括精神运动和视觉运动要素,以及综合的感觉注意和运动表现任务。记录F3和F4的血压、导联心电图和脑电图。配对t检验用于检查这些参数在不同任务中的变化。结果:在视觉运动任务期间,平均动脉压显著降低4.04 mmHg (p = 0.0232),在听觉提示任务期间,平均动脉压显著降低3.38 mmHg (p = 0.0446)。对心率差异的分析显示,被动聆听任务后,心率显著下降3.7次(p < 0.0001 *)。F3和F4的频谱分析显示,低频区的高功率表明在听觉提示和被动聆听时处于放松状态。结论:反应时间模式应用于高血压患者,有助于降低血压和心率,改善心率变异性的高频(HF)成分,表明副交感神经主导。这种奖励导向的模式可能作为生物反馈模块,导致PFC过度活跃,抑制交感神经兴奋回路,增加副交感神经活动,有利于高血压患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Channeling of Brain Towards Engaging Sensorimotor Tasks for Inducing Hedonic Pleasure to Alleviate Blood Pressure in Hypertension.

Channeling of Brain Towards Engaging Sensorimotor Tasks for Inducing Hedonic Pleasure to Alleviate Blood Pressure in Hypertension.

Channeling of Brain Towards Engaging Sensorimotor Tasks for Inducing Hedonic Pleasure to Alleviate Blood Pressure in Hypertension.

Channeling of Brain Towards Engaging Sensorimotor Tasks for Inducing Hedonic Pleasure to Alleviate Blood Pressure in Hypertension.

Background: Hypertension is a modifiable risk factor for cardiovascular disease and is responsible for major deaths due to stroke and coronary heart disease. Several pharmacological and non-pharmacological interventions for reducing blood pressure have been tried earlier. Modulating brain regions such as prefrontal cortex (PFC) to channelize activities is an effective tool to target blood pressure.

Purpose: Prefrontal cortex (PFC) exerts inhibitory control over sympathoexcitatory circuits, which was explored using a novel reaction time paradigm.

Methods: Thirty participants of both genders in the age group 40-70 years with established hypertension were included. A structured reaction time paradigm was designed to include psychomotor and visuomotor elements with integrated sensory attention and motor performance tasks. Blood pressure, Lead II ECG, and EEG from F3 and F4 were recorded. A paired t-test was used to examine the variations in these parameters across tasks.

Results: A significant reduction in mean arterial pressure by 4.04 mmHg (p = .0232) during the visuomotor task and a reduction of 3.38 mmHg during the auditory cue task (p = .0446) were observed. Analysis of the difference in heart rate has shown a profound decrease after passive listening tasks by 3.7 beats (p < .0001*). Spectral analysis from F3 and F4 shows high power in low-frequency zone of EEG indicating a relaxed state during auditory cues and passive listening.

Conclusion: The reaction time paradigm, when applied to hypertensives, helped decrease blood pressure and heart rate and improved the high frequency (HF) component of heart rate variability, indicating parasympathetic dominance. Such reward-oriented paradigms may act as biofeedback modules that cause hyperactivity of the PFC to suppress the sympathoexcitatory circuit with increased parasympathetic activity beneficial to hypertensive individuals.

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来源期刊
Annals of Neurosciences
Annals of Neurosciences NEUROSCIENCES-
CiteScore
2.40
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