单发小皮质下梗死患者早期神经功能恶化入院时症状的预测

IF 2 4区 医学 Q3 CLINICAL NEUROLOGY
Ce Zong, Hongbing Liu, Ke Zhang, Hongxun Yang, Anran Wang, Yunchao Wang, Hanghang Zhu, Yapeng Li, Kai Liu, Bo Song, Yuming Xu, Yuan Gao
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引用次数: 0

摘要

背景:单发小皮质下梗死(SSSI)患者住院期间常发生早期神经功能恶化(END)。然而,入院时的症状在预测END风险方面的表现很少报道。目的:本研究的目的是探讨SSSI患者入院时症状与END之间的关系。方法:对脑卒中发病72小时内出现的皮质纹状动脉(LSA)区域SSSI患者进行前瞻性筛选。收集临床特征,包括入院时的症状、实验室检查和影像学结果。根据受累的身体部位,包括球面脸(SF)、上肢(UL)或下肢(LL),将入院时的症状分为单球面脸(sSF)和任何四肢受累(AL)。END定义为入院后72小时内美国国立卫生研究院卒中量表(NIHSS)总分升高≥2分或运动评分升高≥1分。采用多因素logistic回归分析与END相关的因素。结果:在数据库中的5832例缺血性脑卒中患者中,394例患者最终纳入分析。65例(16.5%)发生END。多变量logistic回归显示,LL (OR 2.337, 95% CI 1.041-5.246)、UL (OR 2.936, 95% CI 1.349-6.390)症状均与END相关,而SF (OR 0.447, 95% CI 0.249-0.804)症状与END相关。进一步分析发现,调整后AL症状(OR 3.958, 95% CI 1.355-11.565)比sSF表现出更高的END风险。结论:我们的结果发现,在SSSI中,AL症状比sSF症状具有更高的END风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prediction of Symptoms on Admission with Early Neurological Deterioration in Single Small Subcortical Infarct.

Background: Early neurological deterioration (END) often occurs during hospitalization in single small subcortical infarct (SSSI). While, symptoms on admission were rarely reported about its performance on predicting the risk of END.

Objectives: The objective of this study is to explore the relationship between symptoms on admission and END in SSSI.

Methods: Patients with SSSI in the lenticulostriate artery (LSA) territory presenting within 72 hours of stroke onset were screened prospectively. Clinical characteristics, including symptoms on admission, laboratory tests and imaging findings, were collected. Based on the body regions involved including spherical face (SF), upper limb (UL) or lower limb (LL), symptoms on admission were classified into single spherical face (sSF) and any involvement of limbs (AL). END was defined as ≥2 points increase in total National Institutes of Health Stroke Scale (NIHSS) score or ≥ 1 point increase in motor score within 72 hours after admission. Multivariate logistic regression was used to analyze factors associated with END.

Results: Out of 5,832 ischemic stroke patients in the database, 394 patients were finally enrolled in analysis. 65 patients (16.5%) developed END. Multivariable logistic regression revealed that symptoms with LL (OR 2.337, 95% CI 1.041-5.246), UL (OR 2.936, 95% CI 1.349-6.390) were both associated with END, while the involvement of SF (OR 0.447, 95% CI 0.249-0.804) showed the opposite result. Further analysis found that symptoms with AL (OR 3.958, 95% CI 1.355-11.565) showed a higher risk of END compared to sSF after adjustment.

Conclusion: Our results discovered that symptoms with AL carried a higher risk of END than those involving sSF in SSSI.

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来源期刊
Current neurovascular research
Current neurovascular research 医学-临床神经学
CiteScore
3.80
自引率
9.50%
发文量
54
审稿时长
3 months
期刊介绍: Current Neurovascular Research provides a cross platform for the publication of scientifically rigorous research that addresses disease mechanisms of both neuronal and vascular origins in neuroscience. The journal serves as an international forum publishing novel and original work as well as timely neuroscience research articles, full-length/mini reviews in the disciplines of cell developmental disorders, plasticity, and degeneration that bridges the gap between basic science research and clinical discovery. Current Neurovascular Research emphasizes the elucidation of disease mechanisms, both cellular and molecular, which can impact the development of unique therapeutic strategies for neuronal and vascular disorders.
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