2.5%双氯芬酸超声偶联贴片持续多小时声学医学治疗的临床透热性能评价。

Tabitha F Hendren, Natalie R Yeretzian, Kiranmayee Bavanasi
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引用次数: 0

摘要

背景:低强度连续超声(LICUS)治疗软组织损伤。它通过其透热和机械传导特性激活多种愈合过程,减轻急性和慢性肌肉骨骼疼痛。双氯芬酸已被fda批准为非甾体抗炎药(NSAID)。它是一种口服和外用的镇痛和消炎药。在超声偶联凝胶中加入2.5%双氯芬酸钠,除了双氯芬酸钠的镇痛作用外,还可以在不改变超声穿透的透热效应和声学效应的情况下传递LICUS,无不良反应。目的:研究超声标准水凝胶中加入2.5%双氯芬酸钠对长时间持续声医学(SAM)超声耦合及透热性能的影响。方法:采用两阶段研究方法,首先用双氯芬酸和2.5%双氯芬酸超声偶联贴片在1 cm、2 cm和5 cm处对牛进行为期4小时的SAM刺激,测定其声学和透热变化。然后,在第二阶段,记录54名健康成人受试者在使用和不使用2.5%双氯芬酸凝胶治疗期间前臂和小腿的加热曲线。结果:2.5%双氯芬酸钠的加入显著增加了偶联凝胶的密度、声阻抗和信号传播。结论:超声凝胶中添加2.5%双氯芬酸钠增加了声阻抗,改善了超声信号进入深部组织的耦合,提供了更持久的深部组织加热,而不会对SAM治疗期间的透热剖面产生负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clinical Diathermy Performance Evaluation of Multi-hour Sustained Acoustic Medicine Treatment with 2.5% Diclofenac Ultrasound Coupling Patch.

Clinical Diathermy Performance Evaluation of Multi-hour Sustained Acoustic Medicine Treatment with 2.5% Diclofenac Ultrasound Coupling Patch.

Clinical Diathermy Performance Evaluation of Multi-hour Sustained Acoustic Medicine Treatment with 2.5% Diclofenac Ultrasound Coupling Patch.

Clinical Diathermy Performance Evaluation of Multi-hour Sustained Acoustic Medicine Treatment with 2.5% Diclofenac Ultrasound Coupling Patch.

Background: Low-intensity Continuous Ultrasound (LICUS) therapy heals soft tissue injuries. It alleviates acute and chronic musculoskeletal pain by activating multiple healing processes through its diathermic and mechanotransducive properties. Diclofenac has been FDA-approved as a Non-Steroidal Anti-Inflammatory Drug (NSAID). It is an analgesic and anti-inflammatory drug available in oral and topical forms. Adding 2.5% diclofenac sodium to ultrasound coupling gel can be used to deliver LICUS in addition to the analgesic effects of diclofenac sodium without altering the diathermic and acoustic effects of the ultrasound penetration with no undesired adverse effects.

Objective: To determine the effects of adding 2.5% diclofenac sodium to standard aqueous ultrasound gel on the ultrasound coupling and diathermic properties of a long duration Sustained Acoustic Medicine (SAM) treatment.

Methods: In a two-phase study, first, the acoustic and diathermic changes were determined in bovine tissue during 4-hour-long SAM stimulation at 1 cm, 2 cm, and 5 cm with aqueous and 2.5% diclofenac ultrasound coupling patch. Then, in the second phase, the heating profiles were recorded with and without 2.5% diclofenac gel in 54 healthy adult subjects at the forearm and calf during the SAM treatment.

Result: The addition of 2.5% diclofenac sodium significantly increased coupling gel density, acoustic impedance, and signal propagation (p<0.0001) with little or no effect on the diathermic profiles at 1 cm, 2 cm, and 5 cm depth. The coupling gel with 2.5% diclofenac sodium sustained the therapeutic ultrasound intensity longer than the aqueous coupling gel (5.5 cm relative to 4.5, p<0.0009). No significant diathermic difference was recorded on the calf and forearm skin with a 2.5% diclofenac ultrasound gel coupling patch.

Conclusion: Adding 2.5% diclofenac sodium to ultrasound gel increases acoustic impedance, improves ultrasound signal coupling into deep tissue, and provides longer sustained deep tissue heating without negatively impacting the diathermic profile during SAM treatment.

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