艾滋病毒感染者的睡眠障碍和慢性疼痛:对艾滋病毒相关神经认知障碍的影响。

IF 1.5 Q4 CLINICAL NEUROLOGY

Current Sleep Medicine Reports Pub Date : 2022-12-01 Epub Date: 2022-11-12 DOI:10.1007/s40675-022-00236-3

Shameka L Cody, Joanna M Hobson, Shannon R Gilstrap, S Justin Thomas, David Galinat, Burel R Goodin

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引用次数: 0

摘要

综述目的:抗逆转录病毒治疗显著降低了艾滋病毒感染者的发病率和死亡率。尽管病毒被抑制，但睡眠障碍、慢性疼痛和神经认知障碍持续存在，这可能会对艾滋病毒感染者的生活质量产生负面影响。本文介绍了艾滋病病毒感染者睡眠障碍和慢性疼痛的相关文献。这些合并症对认知的潜在影响与管理hiv相关神经认知障碍(HAND)的含义进行了讨论。最近的研究发现:与没有慢性疼痛的人相比，感染艾滋病毒和慢性疼痛的人报告的失眠和抑郁症状更严重。艾滋病毒本身的神经毒性作用、睡眠和慢性疼痛引起的炎症会导致较差的认知结果。总结:睡眠障碍和慢性疼痛是艾滋病毒感染者的普遍状况，可能会使HAND的发展和恶化持续下去。睡眠和疼痛干预可以保护艾滋病毒感染者的认知功能并改善他们的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sleep Disturbances and Chronic Pain in People with HIV: Implications for HIV-Associated Neurocognitive Disorders.

Purpose of review: Antiretroviral therapy has significantly reduced morbidity and mortality in people with HIV. Despite being virally suppressed, sleep disturbances, chronic pain, and neurocognitive impairments persist which can negatively impact quality of life for people with HIV. This article presents relevant literature related to sleep disturbances and chronic pain in people with HIV. The potential impact of these comorbidities on cognition is discussed with implications for managing HIV-associated neurocognitive disorder (HAND).

Recent findings: People with HIV and chronic pain report greater insomnia and depressive symptoms compared to those without chronic pain. The neurotoxic effects of HIV itself and sleep and chronic pain induced inflammation can contribute to poorer cognitive outcomes.

Summary: Sleep disturbances and chronic pain are prevalent conditions in people with HIV that may perpetuate the development and exacerbation of HAND. Sleep and pain interventions may preserve cognitive function and improve quality of life for people aging with HIV.

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来源期刊

Current Sleep Medicine Reports Medicine-Pulmonary and Respiratory Medicine

CiteScore

2.50

自引率

5.60%

发文量

期刊介绍： Current Sleep Medicine Reports aims to review the most important, recently published articles in the field of sleep medicine. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of sleep conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as insomnia, narcolepsy, sleep apnea, circadian rhythm disorders, and parasomnias. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.