探索医学-HVTN开发HIV-1广泛中和疫苗的迭代方法。

IF 4.5 3区 医学 Q2 IMMUNOLOGY
Current Opinion in HIV and AIDS Pub Date : 2023-11-01 Epub Date: 2023-09-13 DOI:10.1097/COH.0000000000000821
Troy M Martin, Sam T Robinson, Yunda Huang
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引用次数: 0

摘要

综述目的:在过去的二十年里,HIV-1广泛中和抗体(bnAbs)和诱导它们的相关疫苗策略的发现激增。这种丰富的方法需要一个准确、快速地确定最有前景的治疗方案的系统。我们在此简要回顾了bnAbs的背景科学,提供了第一轮1期发现医学研究的描述,并提出了一种将这些研究整合到全面的HIV-1中和疫苗中的方法。最近的发现:随着最近的临床前成功,包括在小鼠敲除模型和恒河猴中诱导早期bnAbs,在最近的一项人类研究中用eOD-GT8成功启动VRC01类bnAbs以及静脉输注VRC01防止病毒在人类中性传播的概念证明,为广泛而全面的bnAb疫苗计划奠定了基础。利用蛋白质纳米颗粒科学、信使核糖核酸技术、佐剂开发以及B细胞和抗体分析方面的重大进展,HVTN通过开发发现医学计划来重新配置其HIV-1疫苗策略,以测试针对六个关键表位的有前景的候选疫苗。综述:HVTN发现医学项目正在测试多种HIV-1中和候选疫苗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Discovery medicine - the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine.

Discovery medicine - the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine.

Discovery medicine - the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine.

Discovery medicine - the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine.

Purpose of review: In the past two decades, there has been an explosion in the discovery of HIV-1 broadly neutralizing antibodies (bnAbs) and associated vaccine strategies to induce them. This abundance of approaches necessitates a system that accurately and expeditiously identifies the most promising regimens. We herein briefly review the background science of bnAbs, provide a description of the first round of phase 1 discovery medicine studies, and suggest an approach to integrate these into a comprehensive HIV-1-neutralizing vaccine.

Recent findings: With recent preclinical success including induction of early stage bnAbs in mouse knockin models and rhesus macaques, successful priming of VRC01-class bnAbs with eOD-GT8 in a recent study in humans, and proof-of-concept that intravenous infusion of VRC01 prevents sexual transmission of virus in humans, the stage is set for a broad and comprehensive bnAb vaccine program. Leveraging significant advances in protein nanoparticle science, mRNA technology, adjuvant development, and B-cell and antibody analyses, the HVTN has reconfigured its HIV-1 vaccine strategy by developing the Discovery Medicine Program to test promising vaccine candidates targeting six key epitopes.

Summary: The HVTN Discovery Medicine program is testing multiple HIV-1-neutralizing vaccine candidates.

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来源期刊
Current Opinion in HIV and AIDS
Current Opinion in HIV and AIDS IMMUNOLOGY-INFECTIOUS DISEASES
CiteScore
7.40
自引率
7.30%
发文量
115
审稿时长
6-12 weeks
期刊介绍: Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in HIV and AIDS features hand-picked review articles from our team of expert editors. With six disciplines published across the year – including HIV and ageing, a HIV vaccine, and epidemiology – every issue also contains annotated reference detailing the merits of the most important papers.
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