Moisés Mier-Martínez, Luis García-Benítez, Verónica Santiago-Vázquez, Orlando Tamariz-Cruz
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We analyzed three groups: < 250 m ASL (group 1), 1500 m ASL (group 2), and 2250 m ASL (group 3).</p><p><strong>Results: </strong>The mean S<sub>a</sub>O<sub>2</sub> was 97.6 ± 1.8%. For group 1, mean oxygen saturation was 98.2 ± 1.9%; for group 2, 96.7 ± 1.9%, and for group 3, 96.0 ± 2.1%. A statistically significant difference was observed among the groups (p < 0.001), and this difference was higher between groups 1 and 2 (1.5%, p < 0.001). Linear regression analysis showed a decrease in oxygen saturation of 1.01% for every 1000 m ASL.</p><p><strong>Conclusions: </strong>We demonstrated a statistically significant reduction in S<sub>a</sub>O<sub>2</sub> levels at higher altitudes. 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引用次数: 0
摘要
背景：动脉血氧饱和度（SaO2）值用于做出可能改变患者预后的临床决策，并被认为是第五个生命体征。本研究旨在确定健康的墨西哥足月新生儿在不同海拔高度（ASL）的SaO2变化。方法：从2018年7月到2019年6月，在墨西哥ASL不同海拔高度的六家医院进行了一项交叉研究。4015名新生儿在出生后24小时和出院前使用脉搏血氧计测量了SaO2。我们分析了三组：<250 m ASL（第1组）、1500 m ASL、2250 m ASL。结果：SaO2平均值为97.6±1.8%，1组平均血氧饱和度为98.2±1.9%；第2组为96.7±1.9%，第3组为96.0±2.1%。各组之间存在统计学显著差异（p＜0.001），第1组和第2组之间的差异更大（1.5%，p＜0.001。线性回归分析显示，每1000m ASL的血氧饱和度下降1.01%。结论：我们证明，在海拔较高的地区，SaO2水平在统计学上显著降低。这一观察结果可能与基于脉搏血氧计的临床决策有关，例如墨西哥的关键先天性心脏病筛查，该国一半以上的人口生活在海拔1500米以上。
Arterial oxygen saturation in healthy Mexican full-term newborns at different altitudes above sea level.
Background: Arterial oxygen saturation (SaO2) values are used to make clinical decisions that might change a patient's prognosis, and it has been proposed as the fifth vital sign. This study aimed to determine the variation of SaO2 at different altitudes above sea level (ASL) in healthy Mexican full-term newborns.
Methods: From July 2018 to June 2019, a cross-over study was conducted in six hospitals at different altitudes ASL in Mexico. SaO2 was measured in 4015 newborns after the first 24 h of birth and before leaving the hospital using pulse oximetry. We analyzed three groups: < 250 m ASL (group 1), 1500 m ASL (group 2), and 2250 m ASL (group 3).
Results: The mean SaO2 was 97.6 ± 1.8%. For group 1, mean oxygen saturation was 98.2 ± 1.9%; for group 2, 96.7 ± 1.9%, and for group 3, 96.0 ± 2.1%. A statistically significant difference was observed among the groups (p < 0.001), and this difference was higher between groups 1 and 2 (1.5%, p < 0.001). Linear regression analysis showed a decrease in oxygen saturation of 1.01% for every 1000 m ASL.
Conclusions: We demonstrated a statistically significant reduction in SaO2 levels at higher altitudes. This observation can be relevant for clinical decision-making based on pulse oximetry such as critical congenital heart disease screening in Mexico, where more than half of the population lives above 1500 m ASL.
期刊介绍：
The Boletín Médico del Hospital Infantil de México is a bimonthly publication edited by the Hospital Infantil de México Federico Gómez. It receives unpublished manuscripts, in English or Spanish, relating to paediatrics in the following areas: biomedicine, clinical, public health, clinical epidemology, health education and clinical ethics. Articles can be original research articles, in-depth or systematic reviews, clinical cases, clinical-pathological cases, articles about public health, letters to the editor or editorials (by invitation).
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