使用基于生理学的药代动力学模型估计挥发性有机化合物暴露浓度和达到特定皮肤吸收的时间。

IF 1.5 4区 医学 Q4 ENVIRONMENTAL SCIENCES
Laurent Simon
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引用次数: 0

摘要

提出了一种基于在大鼠中开发的基于生理学的药代动力学(PBPK)模型来估计皮肤暴露的程序。这项研究检测了500至10000之间的蒸汽浓度 二溴甲烷的ppm和2500至40000 溴氯甲烷的ppm。这些浓度是根据4 小时,误差从0.0%到52.0%不等。PBPK方法充分预测了血液浓度,并有助于模拟污染物通过角质层的传输和在身体隔间中的分布。所提出的技术可以估计从急性吸入毒性数据中获得的皮肤吸收时间(SAT)。SAT和暴露浓度之间存在相反的关系。该方法可用于危险挥发性有机物的毒理学和风险评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Estimation of volatile organic compound exposure concentrations and time to reach a specific dermal absorption using physiologically based pharmacokinetic modeling.

A procedure was proposed to estimate dermal exposures based on a physiologically based pharmacokinetic (PBPK) model developed in rats. The study examined vapor concentrations ranging from 500 to 10,000 ppm for dibromomethane and 2,500 to 40,000 ppm for bromochloromethane. These concentrations were reconstructed based on chemical blood levels measured in 4 hr, with errors varying from 0.0% to 52.0%. The PBPK approach adequately predicted the blood concentrations and helped simulate contaminant transport through the stratum corneum and distribution in the body compartments. The proposed technique made it possible to estimate the skin absorption time (SAT) obtained from acute inhalation toxicity data. An inverse relationship exists between the SAT and exposure concentration. The method can be helpful in toxicology and risk assessment of hazardous volatile organic compounds.

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来源期刊
Journal of Occupational and Environmental Hygiene
Journal of Occupational and Environmental Hygiene 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
3.30
自引率
10.00%
发文量
81
审稿时长
12-24 weeks
期刊介绍: The Journal of Occupational and Environmental Hygiene ( JOEH ) is a joint publication of the American Industrial Hygiene Association (AIHA®) and ACGIH®. The JOEH is a peer-reviewed journal devoted to enhancing the knowledge and practice of occupational and environmental hygiene and safety by widely disseminating research articles and applied studies of the highest quality. The JOEH provides a written medium for the communication of ideas, methods, processes, and research in core and emerging areas of occupational and environmental hygiene. Core domains include, but are not limited to: exposure assessment, control strategies, ergonomics, and risk analysis. Emerging domains include, but are not limited to: sensor technology, emergency preparedness and response, changing workforce, and management and analysis of "big" data.
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