与长期新冠肺炎相关的身体健康和精神疲劳障碍：美国全国队列的基线结果。

IF 2.5 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

American Journal of Medicine Pub Date : 2025-02-01 DOI:10.1016/j.amjmed.2023.08.009

Bryan Lau PhD, MHS, ScM, Eryka Wentz MA, Zhanmo Ni MHS, Karine Yenokyan PhD, Candelaria Vergara MD, Shruti H. Mehta PhD, MPH , Priya Duggal PhD, MPH

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引用次数: 0

摘要

背景：10%-55%的人出现严重急性呼吸系统疾病冠状病毒2型（严重急性呼吸综合征冠状病毒2型；长期新冠肺炎）后的持续症状，但对日常功能和残疾的影响仍未量化。方法：为了描述与长期新冠肺炎相关的残疾，我们分析了一项基于美国的在线队列研究的基线数据。成年参与者包括报告有新冠肺炎病史（n=8874）或从未患有新冠肺炎（n=633）但无残疾的人。主要结果是自我报告的身体活动能力、日常生活工具性活动（IADL）和精神疲劳残疾，通过测量5个残疾组成部分进行评估：行走四分之一英里或爬10级楼梯的困难（活动能力）、做轻或重家务的困难（IADL，结果：在7926名长期新冠肺炎患者中，65%的患者至少有一种残疾，而新冠肺炎和无新冠肺炎的患者分别为6%和14%。此外，22%的人在所有三个类别中都被归类为残疾人。年龄、既往合并症、体重指数增加、女性、新冠肺炎住院治疗、非白人/多种族与较高的残疾负担相关。无论是否住院，感染时头晕和四肢沉重都与残疾有关。呼吸困难和震颤与非住院患者的残疾有关。接种疫苗可以预防残疾。结论：我们观察到与长期新冠肺炎相关的新残疾负担很高，这对个人和社会健康有严重影响。对新冠肺炎患者进行纵向评估对于确定康复模式和治疗方案是必要的。

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Physical Health and Mental Fatigue Disability Associated with Long COVID: Baseline Results from a US Nationwide Cohort

Background

Persistent symptoms after severe acute respiratory disease coronavirus 2 (SARS-COV-2; long COVID) occur in 10%-55% of individuals, but the impact on daily functioning and disability remains unquantified.

Methods

To characterize disability associated with long COVID, we analyzed baseline data from an online, US-based cohort study. Adult participants included those reporting a history of COVID-19 (n = 8874) or never having COVID-19 (n = 633) without prior disability. The main outcomes were self-reported physical mobility, instrumental activities of daily living (IADL), and mental fatigue disability, assessed by measuring 5 disability components: difficulty walking a quarter mile or climbing 10 stairs (mobility), difficulty doing light or heavy housework (IADL), and Wood Mental Fatigue Inventory score (mental fatigue).

Results

Of 7926 participants with long COVID, 65% were classified with at least one disability, as compared with 6% and 14% for resolved COVID and no COVID, respectively. Additionally, 22% were classified as disabled in all 3 categories. Age, prior comorbidity, increased body mass index, female sex, COVID-19 hospitalization, non-white/multi-race were associated with higher disability burden. Dizziness and heavy limbs at infection were associated with disability regardless of hospitalization. Dyspnea and tremors were associated with disability in non-hospitalized individuals. Vaccination was protective against disability.

Conclusions

We observed a high burden of new disability associated with long COVID, which has serious implications for individual and societal health. Longitudinal evaluation of COVID-19 patients is necessary to identify patterns of recovery and treatment options.

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来源期刊

American Journal of Medicine 医学-医学：内科

CiteScore

6.30

自引率

3.40%

发文量

449

审稿时长

9 days

期刊介绍： The American Journal of Medicine - "The Green Journal" - publishes original clinical research of interest to physicians in internal medicine, both in academia and community-based practice. AJM is the official journal of the Alliance for Academic Internal Medicine, a prestigious group comprising internal medicine department chairs at more than 125 medical schools across the U.S. Each issue carries useful reviews as well as seminal articles of immediate interest to the practicing physician, including peer-reviewed, original scientific studies that have direct clinical significance and position papers on health care issues, medical education, and public policy.