通过 2-氨基苯并咪唑、苯乙酮和 N,N-二甲基甲酰胺的单碳合成（3 + 2 + 1）环化合成苯并[4,5]咪唑并[1,2-a]嘧啶。

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

The Journal of Organic Chemistry Pub Date : 2024-10-18 Epub Date: 2023-09-12 DOI:10.1021/acs.joc.3c01227

Mengyi Guo, Xin Huang, Suzhen Li, Wanqian Ma, Aqin Liu, Xiuyu Zhang, Qiulin Kuang, Luoteng Cheng, Yibo Song, Xueyuan Hu, Jianyong Yuan

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引用次数: 0

摘要

介绍了一种以 N,N-二甲基甲酰胺为一碳源，以 2-氨基苯并咪唑和苯乙酮为底物，通过一锅三组份级联反应制备苯并[4,5]咪唑并[1,2-a]嘧啶的高效方法。光谱研究表明，所选产物具有荧光特性，量子产率为 0.07-0.16，最大吸收波长为 266-294 纳米，发射波长为 472-546 纳米。

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Synthesis of Substituted of Benzo[4,5]imidazo[1,2-a]pyrimidines through (3 + 2+1) Cyclization of 2-Aminobenzimidazole, Acetophenone, and N,N-Dimethylformamide as One-Carbon Synthon.

An efficient method for the construction of benzo[4,5]imidazo[1,2-a]pyrimidines using N,N-dimethylformamide as a one-carbon source and 2-aminobenzimidazoles and acetophenone as substrates through a one-pot, three-component cascade reaction is described. Spectra investigations indicated the fluorescent properties of selected products, exhibiting quantum yields 0.07-0.16 with maxima absorption at 266-294 nm and emission at 472-546 nm.

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来源期刊

The Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.