海洋真菌产黄青霉Y20-2的次级代谢产物及其促血管生成活性。

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2023-06-26 Print Date: 2023-09-26 DOI:10.1515/znc-2022-0198

Yue-Zi Qiu, Yong-Qiang Zhu, Hong Lu, Xiao-Bin Li, Ke-Chun Liu, Pei-Hai Li, Li-Zhen Wang, Xuan-Ming Zhang, Hao Chen, Hou-Wen Lin, Shan-Shan Zhang

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引用次数: 0

摘要

对海洋真菌产黄青霉（编号Y20-2）的次级代谢产物进行了系统的化学研究，分离出21种化合物，其中一种是新化合物（化合物3）。通过对光谱数据进行广泛分析，确定了21种化合物的结构。使用斑马鱼模型评估每种化合物的促血管生成活性。结果表明，化合物7、9、16和17具有强且剂量依赖性的促血管生成作用，其中化合物16表现出最强的促血管形成活性，化合物6、12、14和18表现出中等活性，化合物8、13和19表现出相对较弱的活性。

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Secondary metabolites from the marine-derived fungus Penicillium chrysogenum Y20-2, and their pro-angiogenic activity.

A systematic chemical study of the secondary metabolites of the marine fungus, Penicillium chrysogenum (No. Y20-2), led to the isolation of 21 compounds, one of which is new (compound 3). The structures of the 21 compounds were determined by conducting extensive analysis of the spectroscopic data. The pro-angiogenic activity of each compound was evaluated using a zebrafish model. The results showed that compounds 7, 9, 16, and 17 had strong and dose-dependent pro-angiogenic effects, with compound 16 demonstrating the strongest pro-angiogenic activity, compounds 6, 12, 14, and 18 showing moderate activity, and compounds 8, 13, and 19 exhibiting relatively weak activity.

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来源期刊

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences 生物-生化与分子生物学

CiteScore

4.10

自引率

5.00%

发文量

期刊介绍： A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products. The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products. A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.