Enhui Jiang, Hongyang Wang, Xuelan Li, Yi Bi, Cui Mao, Fugui Jiang, Enliang Song, Xianyong Lan
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引用次数: 0
摘要
EPAS1（Endothelial PAS Domain Protein 1）基因因其在高原缺氧适应性方面的功能而闻名。它编码 HIF-2α，后者参与诱导受氧调控的基因，进而影响血管生成和能量代谢等多个生理过程。这些都表明它可能会影响动物的发育。本研究在山东黑牛群体（n = 502）中发现了 EPAS1 基因的 14-bp 缺失。发现了两种基因型（II 型和 ID 型），且同源 II 型基因型的频率高于杂合 ID 型基因型。该群体与 HWE 一致（p > 0.05）。更重要的是，14-bp 缺失与外扁平（p = 0.003）、牛腩（p = 0.001）和指节（p = 0.032）相关。这些发现表明，14-bp 缺失与胴体性状显著相关，可作为分子标记应用于奶牛育种。
A 14-bp deletion in bovine EPAS1 gene is associated with carcass traits.
EPAS1 (Endothelial PAS Domain Protein 1) gene is well-known for its function in plateau hypoxia adaptability. It encodes HIF-2α, which involved in the induction of genes regulated by oxygen and then affects multiple physiological processes such as angiogenesis and energy metabolism. All of these indicate it may affect the development of animals. In this study, a 14-bp deletion in EPAS1 gene was uncovered in Shandong black cattle population (n = 502). Two genotypes (II and ID) were found and the frequency of the homozygous II genotype is higher than the heterozygous ID genotype. This population is consisted with HWE (p > 0.05). And more importantly, the 14-bp deletion was associated with outside flat (p = 0.003), brisket (p = 0.001), and knuckle (p = 0.032). These findings suggested that the 14-bp deletion is significantly associated with carcass traits, which could be served as a molecular marker applied to cow breeding.
期刊介绍：
Biotechnology can be defined as any technique that uses living organisms (or parts of organisms like cells, genes, proteins) to make or modify products, to improve plants, animals or microorganisms for a specific use. Animal Biotechnology publishes research on the identification and manipulation of genes and their products, stressing applications in domesticated animals. The journal publishes full-length articles and short research communications, as well as comprehensive reviews. The journal also provides a forum for regulatory or scientific issues related to cell and molecular biology applied to animal biotechnology.
Submissions on the following topics are particularly welcome:
- Applied microbiology, immunogenetics and antibiotic resistance
- Genome engineering and animal models
- Comparative genomics
- Gene editing and CRISPRs
- Reproductive biotechnologies
- Synthetic biology and design of new genomes
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