在已发表的文献中,临床前放射生物学照射器和剂量学的最低报告标准应该是预期的。

IF 2.1 4区 医学 Q2 BIOLOGY
François Trompier, Larry A DeWerd, Yannick Poirier, Morgane Dos Santos, Ke Sheng, Keith A Kunugi, Thomas A Winters, Andrea L DiCarlo, Merriline Satyamitra
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引用次数: 0

摘要

科学进步的基石是进行科学研究的严谨性、研究结果的可重复性以及对实验设计和结果的公正报道。对于辐射研究,这需要严格描述实验细节以及准确、精确和可重复的剂量测定的辐射方案。大多数在体外或动物模型中进行辐射生物学研究的机构没有足够详细地描述实验辐射方案,无法对其出版物进行平衡审查,也无法让其他研究人员复制已发表的实验。十多年来,美国和法国都注意到需要增加和改进剂量学标准,可追溯国家标准与技术研究所(NIST)标准光束线,并在辐射生物学社区内提供剂量学协调。为了满足这一要求,主题专家概述了临床前照射器和剂量学应包括在已发表的文献中的最低报告标准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Minimum reporting standards should be expected for preclinical radiobiology irradiators and dosimetry in the published literature.

The cornerstones of science advancement are rigor in performing scientific research, reproducibility of research findings and unbiased reporting of design and results of the experiments. For radiation research, this requires rigor in describing experimental details as well as the irradiation protocols for accurate, precise and reproducible dosimetry. Most institutions conducting radiation biology research in in vitro or animal models do not have describe experimental irradiation protocols in sufficient details to allow for balanced review of their publication nor for other investigators to replicate published experiments. The need to increase and improve dosimetry standards, traceability to National Institute of Standards and Technology (NIST) standard beamlines, and to provide dosimetry harmonization within the radiation biology community has been noted for over a decade both within the United States and France. To address this requirement subject matter experts have outlined minimum reporting standards that should be included in published literature for preclinical irradiators and dosimetry.

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来源期刊
CiteScore
5.00
自引率
11.50%
发文量
142
审稿时长
3 months
期刊介绍: The International Journal of Radiation Biology publishes original papers, reviews, current topic articles, technical notes/reports, and meeting reports on the effects of ionizing, UV and visible radiation, accelerated particles, electromagnetic fields, ultrasound, heat and related modalities. The focus is on the biological effects of such radiations: from radiation chemistry to the spectrum of responses of living organisms and underlying mechanisms, including genetic abnormalities, repair phenomena, cell death, dose modifying agents and tissue responses. Application of basic studies to medical uses of radiation extends the coverage to practical problems such as physical and chemical adjuvants which improve the effectiveness of radiation in cancer therapy. Assessment of the hazards of low doses of radiation is also considered.
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