钙活性的峰值检测。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-11-01 DOI:10.1515/ijb-2020-0043

Hermine Biermé, Camille Constant, Anne Duittoz, Christine Georgelin

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引用次数: 0

摘要

我们提出了一种在荧光记录gnrh神经元钙活性的生物学背景下的spike检测的全球方法。为此，我们首先提出一个简单的随机模型，该模型可以通过考虑具有线性趋势的自回归AR(1)过程和涉及峰值时间的特定创新来模拟实验时间序列。建立了具有渐近正态性的参数估计量，并用于对估计的创新进行统计检验，以便检测峰值。我们比较了几种程序，并用生物学数据说明了我们程序的性能。

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Spike detection for calcium activity.

We present in this paper a global methodology for the spike detection in a biological context of fluorescence recording of GnRH-neurons calcium activity. For this purpose we first propose a simple stochastic model that could mimic experimental time series by considering an autoregressive AR(1) process with a linear trend and specific innovations involving spiking times. Estimators of parameters with asymptotic normality are established and used to set up a statistical test on estimated innovations in order to detect spikes. We compare several procedures and illustrate on biological data the performance of our procedure.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.