用于123I-FP-CIT SPECT的带有双头镉锌碲化探测器的高分辨率全身SPECT/CT设备准直器的评估

IF 1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Hitoshi Hiraki, Toshimune Ito, Masahisa Onoguchi, Hirotatsu Tsuchikame, Masaaki Shishido, Takafumi Maeno, Takayuki Shibutani, Hiroki Sanada
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引用次数: 0

摘要

本研究的目的是评估准直器与123i - n -氟丙基-2b-碳甲氧基-3b-(4-碘苯基)-北tropane (123I-FP-CIT)多巴胺转运体SPECT (datc -SPECT)在图像质量、定量、诊断性能和采集时间方面的适应性,该系统采用高分辨率全身SPECT/CT系统与镉-碲化锌探测器(C-SPECT)。方法:采用配备宽能量、高分辨率准直器和中能量、高灵敏度(MEHRS)准直器的C-SPECT装置,对拟人纹状体幻像的成像质量和定量进行评价。采用分辨率恢复、散射和衰减校正的有序子集期望最大化迭代重建,并根据对比噪声比(CNR)、百分比对比度和特定绑定比确定最佳准直器。确定了使用最优准直器可以减少的采集时间。通过对41例连续接受DAT-SPECT的患者的受体-操作特征分析和特异性结合比率,使用最佳准直器回顾性评估诊断准确性。结果:对两种准直器进行幻像验证时,MEHRS准直器的CNR和百分比对比度显著高于宽能高分辨率准直器(P < 0.05)。在使用MEHRS准直器的30和15分钟成像时间之间,CNR没有显着差异。在临床研究中,采集时间为30 min和15 min时的曲线下面积分别为0.927和0.906,两次之间DAT-SPECT图像的诊断准确率无显著差异。结论:MEHRS准直仪对DAT-SPECT和C-SPECT的成像效果最好;更短的采集时间(
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Collimators in a High-Resolution, Whole-Body SPECT/CT Device with a Dual-Head Cadmium-Zinc-Telluride Detector for 123I-FP-CIT SPECT.

The study aim was to evaluate the adaptation of collimators to 123I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl)nortropane (123I-FP-CIT) dopamine transporter SPECT (DAT-SPECT) by a high-resolution whole-body SPECT/CT system with a cadmium-zinc-telluride detector (C-SPECT) in terms of image quality, quantitation, diagnostic performance, and acquisition time. Methods: Using a C-SPECT device equipped with a wide-energy, high-resolution collimator and a medium-energy, high-resolution sensitivity (MEHRS) collimator, we evaluated the image quality and quantification of DAT-SPECT for an anthropomorphic striatal phantom. Ordered-subset expectation maximization iterative reconstruction with resolution recovery, scatter, and attenuation correction was used, and the optimal collimator was determined on the basis of the contrast-to-noise ratio (CNR), percentage contrast, and specific binding ratio. The acquisition time that could be reduced using the optimal collimator was determined. The optimal collimator was used to retrospectively evaluate diagnostic accuracy via receiver-operating-characteristic analysis and specific binding ratios for 41 consecutive patients who underwent DAT-SPECT. Results: When the collimators were compared in the phantom verification, the CNR and percentage contrast were significantly higher for the MEHRS collimator than for the wide-energy high-resolution collimator (P < 0.05). There was no significant difference in the CNR between 30 and 15 min of imaging time using the MEHRS collimator. In the clinical study, the areas under the curve for acquisition times of 30 and 15 min were 0.927 and 0.906, respectively, and the diagnostic accuracies of the DAT-SPECT images did not significantly differ between the 2 times. Conclusion: The MEHRS collimator provided the best results for DAT-SPECT with C-SPECT; shorter acquisition times (<15 min) may be possible with injected activity of 167-186 MBq.

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来源期刊
Journal of nuclear medicine technology
Journal of nuclear medicine technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.90
自引率
15.40%
发文量
57
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