Lukasz Janas, Grzegorz Stachowiak, Ewa Glowacka, Iwona Piwowarczyk, Magdalena Kajdos, Malwina Soja, Martyna Masternak, Marek Nowak
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引用次数: 0
摘要
目的比较CA125、人附睾蛋白4（HE4）、卵巢恶性肿瘤风险算法（ROMA）、恶性肿瘤风险指数（RMI）和主观评估（SA）在卵巢肿瘤术前诊断中的作用：研究对象为456名符合手术条件的卵巢肿瘤患者。术前估测 CA125 和 HE4 血清水平，并进行经阴道超声检查。获得了 ROMA 和 RMI 值以及 SA 资格。结果与病理形态学结果进行了比较：CA125、HE4、ROMA、RMI和SA在恶性病变术前诊断中的受试者操作特征曲线（ROC）-曲线下面积（AUC）值分别为0.819、0.909、0.911、0.895和0.895。生化和超声方法的组合提高了卵巢肿瘤诊断的灵敏度。结论：结论：CA125、HE4、ROMA、RMI 和 SA 被证明对卵巢肿瘤的术前诊断有用。HE4和ROMA最有用。超声波方法对卵巢肿瘤的诊断非常有用。RMI和SA具有相似的总体诊断价值。
The use of CA125, human epididymis protein 4 (HE4), risk of ovarian malignancy algorithm (ROMA), risk of malignancy index (RMI) and subjective assessment (SA) in preoperative diagnosing of ovarian tumors.
Objectives: To compare utility of CA125, human epididymis protein 4 (HE4), risk of ovarian malignancy algorithm (ROMA), risk of malignancy index (RMI) and subjective assessment (SA) in preoperative diagnosis of ovarian tumors.
Material and methods: Research was conducted among 456 patients qualified for surgery due to ovarian tumor. Preoperatively, CA125 and HE4 serum levels were estimated, and transvaginal ultrasound was performed. ROMA and RMI values and SA qualifications were obtained. Results were compared with pathomorphological findings.
Results: Receiver Operating Characteristic (ROC)-Area Under Curve (AUC) values for CA125, HE4, ROMA, RMI and SA in preoperative diagnosis of malignant lesions were 0.819, 0.909, 0.911, 0.895 and 0.895, respectively. Combinations of biochemical and sonographic methods increased sensitivity in diagnosis of ovarian tumors. Combinations utilizing serum HE4 concentrations were most useful.
Conclusions: CA125, HE4, ROMA, RMI and SA proved to be useful in preoperative diagnosis of ovarian tumors. HE4 and ROMA occurred to be the most useful. Ultrasonographic methods are considerably useful in diagnosis of ovarian tumors. RMI and SA present similar overall diagnostic value.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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