妊娠早期的红细胞脂肪酸和去饱和酶指数与先兆子痫的风险相关。

IF 3
A.A. Godhamgaonkar , N.S. Wadhwani , K.N. Randhir , S.S. Selukar , S. Dalvi , K. Dangat , G.N. Wagh , S. Lalwani , N. Chandhiok , B. Kulkarni , C. Fall , H.P.S. Sachdev , S. Gupte , S.R. Joshi
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引用次数: 0

摘要

先兆子痫(PE)是一种妊娠期疾病,可能与母体营养不足有关。脂肪酸对胎盘和胎儿的生长至关重要。脂肪酸去饱和酶是影响多不饱和脂肪酸代谢的关键酶,据报道与心脏代谢风险有关。ω-3和ω-6脂肪酸水平的任何失衡都会导致炎症反应增加。目前的研究报告了发生PE的女性(n=108)在整个妊娠期的红细胞脂肪酸水平和去饱和酶指数,并将其与非PE女性(n=216)进行了比较。使用气相色谱法在妊娠期间的4个时间点(即11-14、18-22、26-28周和分娩时)测量母体红细胞脂肪酸。在11-14周和18-22周时,PE组的母体红细胞总饱和脂肪酸和ω-6/ω-3脂肪酸比率分别高于非PE组。PE组在11-14周和18-22周时母体Δ5去饱和酶指数较低,而Δ6去饱和酶指标较高。母体硬脂酰辅酶A去饱和酶-18(SCD-18)指数在11-14周和分娩时较低。这些变化主要在早发PE(EOP)组中观察到。Δ6去饱和酶指数在11-14周预测EOP的风险。脂肪酸水平和去饱和酶指数的失衡早于PE的临床诊断,表明它们在其病理生理学中的作用。妊娠早期脂肪酸和去饱和酶指数的测量值得评估为PE风险的预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Erythrocyte fatty acids and desaturase indices in early pregnancy are associated with risk of preeclampsia

Preeclampsia (PE) is a pregnancy disorder that may be associated with inadequate maternal nutrition. Fatty acids are vital for placental and fetal growth. Fatty acid desaturases, key enzymes influencing the metabolism of polyunsaturated fatty acids, are reported to be associated with cardiometabolic risk. Any imbalance in the levels of omega-3 and omega-6 fatty acids can result in increased inflammatory response. The current study reports the levels of erythrocyte fatty acids and desaturase index across gestation in women who develop PE (n = 108) and compares them with non-PE women (n = 216). Maternal erythrocyte fatty acids were measured at 4 time points during pregnancy (i.e., 11–14, 18–22, 26–28 weeks and at delivery) using gas chromatography. Maternal total erythrocyte saturated fatty acids and omega-6/omega-3 fatty acid ratio was higher in the PE group as compared to the non-PE group at 11–14 weeks and 18–22 weeks respectively. Maternal Δ5 desaturase index was lower while Δ6 desaturase index was higher in the PE group at 11–14 and 18–22 weeks. Maternal stearoyl CoA desaturase-18 (SCD-18) index was lower at 11–14 weeks and at delivery. These changes were mainly observed in the early onset PE (EOP) group. Δ6 desaturase index at 11–14 weeks predicted the risk of EOP. Imbalance in fatty acid levels and desaturase indices predate the clinical diagnosis of PE, indicating their role in its pathophysiology. Measurement of fatty acids and desaturase indices in early pregnancy merits evaluation as predictors of risk of PE.

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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
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