阿列克谢-奥洛夫尼科夫：超越边缘的理论生物学。

IF 4.4 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2024-04-01 Epub Date: 2023-09-07 DOI:10.1007/s10522-023-10061-y

Ivan A Olovnikov

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引用次数: 0

摘要

阿列克谢-奥洛夫尼科夫（Alexey Olovnikov，1936-2022 年）是著名的边缘切开假说（marginotomy hypothesis）的提出者，他在该假说中认识到了 DNA 末端复制问题及其在细胞衰老中的作用。在本传记中，我们将庆祝这一理论发现 50 周年，这一发现后来得到了辉煌的证实，并催生了分子生物学和老年学这一新领域的蓬勃发展。我们还将回顾阿列克谢-奥洛夫尼科夫毕生探索衰老分子机制的思想演变过程，探讨他为何放弃最初关于端粒在衰老中的关键作用的结论，并建立起一个连接本体发生各个阶段的新的庞大理论体系。

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Alexey Olovnikov: theoretical biology beyond the margins.

Alexey Olovnikov (1936-2022) is an author of the famous marginotomy hypothesis, where he recognized the DNA end replication problem and its role in cell aging. In this biographical note we celebrate the 50th anniversary of this theoretical discovery that later enjoyed a brilliant confirmation and gave rise to a new thriving field of molecular biology and gerontology. We also take a look at the evolution of ideas in Alexey Olovnikov's lifelong quest to uncover the molecular mechanisms of aging, exploring the reasons why he walked away from his initial conclusion about the key role of telomeres in aging, and built a new vast theoretical landscape that linked all stages of ontogenesis.

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.