肠道屏障微生物群对 17 型免疫的情境依赖性调控

IF 4.3 4区 医学 Q2 IMMUNOLOGY
Immune Network Pub Date : 2022-09-26 eCollection Date: 2022-12-01 DOI:10.4110/in.2022.22.e46
Begum Akuzum, June-Yong Lee
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引用次数: 0

摘要

T-17(Th17)细胞和相关的产生 IL-17 的(17 型)淋巴细胞在上皮屏障中大量存在。在应对细菌和真菌感染时,标志性细胞因子 IL-17A/F 和 IL-22 介导抗微生物免疫反应,并促进受伤组织的伤口愈合。尽管 17 型淋巴细胞具有保护功能,但它们也是各种慢性炎症性疾病的罪魁祸首,包括炎症性肠病(IBD)和结肠炎相关癌症(CAC)。深入了解 17 型淋巴细胞的调控机制,最终将有助于发现治疗慢性炎症性疾病和预防癌症的治疗策略。在这篇综述中,我们将讨论目前对 17 型免疫细胞在肠道屏障上的发育和功能的理解,重点是微生物-免疫相互作用对肠道屏障稳态和疾病病因学的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier.

Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier.

Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier.

Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier.

T-helper-17 (Th17) cells and related IL-17-producing (type17) lymphocytes are abundant at the epithelial barrier. In response to bacterial and fungal infection, the signature cytokines IL-17A/F and IL-22 mediate the antimicrobial immune response and contribute to wound healing of injured tissues. Despite their protective function, type17 lymphocytes are also responsible for various chronic inflammatory disorders, including inflammatory bowel disease (IBD) and colitis associated cancer (CAC). A deeper understanding of type17 regulatory mechanisms could ultimately lead to the discovery of therapeutic strategies for the treatment of chronic inflammatory disorders and the prevention of cancer. In this review, we discuss the current understanding of the development and function of type17 immune cells at the intestinal barrier, focusing on the impact of microbiota-immune interactions on intestinal barrier homeostasis and disease etiology.

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来源期刊
Immune Network
Immune Network Immunology and Microbiology-Immunology
CiteScore
2.90
自引率
3.30%
发文量
36
期刊介绍: Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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