石墨烯/羟基磷灰石涂层沉积在钛合金上用于植入应用。

IF 3.1 4区 医学 Q2 BIOPHYSICS
Wufanbieke Baheti, ShangYi Lv, Mila, Lisha Ma, Dumanbieke Amantai, Hao Sun, HuiYu He
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引用次数: 2

摘要

钛(Ti)植入物广泛应用于医学。同时,钛的表面修饰可以增强种植体的骨整合。在本研究中,我们通过电泳沉积对钛植入物表面进行修饰,分别涂覆氧化石墨烯、透明质酸、HA-2wt%氧化石墨烯和HA-5wt%氧化石墨烯,研究其作用机制和生物活性。以未包覆Ti为对照。此外,我们还研究了体外培养的小鼠骨髓间充质干细胞(BMSCs)的生物学行为和成骨性能。我们发现HA-GO纳米复合涂层改善了Ti表面的粗糙度和亲水性。与未涂覆的Ti或单独经HA或GO修饰的Ti相比,细胞在HA-GO修饰的Ti表面的粘附和扩散增强。此外,ha - go修饰表面可显著促进BMSCs体外增殖和成骨分化,而成骨相关基因表达和碱性磷酸酶活性则略有增强。此外,我们注意到HA-2wt%氧化石墨烯组体内骨再生得到改善。因此,HA-2wt%氧化石墨烯纳米复合涂层在种植牙领域具有潜在的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Graphene/hydroxyapatite coating deposit on titanium alloys for implant application.

Titanium (Ti) implants are widely used in medicine. Meanwhile, surface modification of Ti can strengthen the osseointegration of implants. In this study, we modified Ti implant surfaces, which was coated with GO, HA, HA-2wt%GO and HA-5wt%GO via electrophoresis deposition, to investigate their mechanisms and biological activity. Uncoated Ti was used as the control. Further, we examined the biological behavior and osteogenic performance of mouse bone marrow mesenchymal stem cells (BMSCs) cultured on coatings in vitro. We found that the HA-GO nanocomposite coating improved the roughness and hydrophilicity of the Ti surface. Compared with the uncoated Ti or Ti modified by HA or GO alone, cell adhesion and diffusion were enhanced on HA-GO-modified Ti surfaces. In addition, the proliferation and osteogenic differentiation of BMSCs in vitro were significantly improved on HA-GO-modified surfaces, whereas osteogenesis-related gene expression and alkaline phosphatase activity were slightly enhanced. Furthermore, we noted that bone regeneration was improved in the HA-2wt%GO group in vivo. Thus, the HA-2wt%GO nanocomposite coating might have potential applications in the field of dental implants.

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来源期刊
Journal of Applied Biomaterials & Functional Materials
Journal of Applied Biomaterials & Functional Materials BIOPHYSICS-ENGINEERING, BIOMEDICAL
CiteScore
4.40
自引率
4.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials. The areas covered by the journal will include: • Biomaterials / Materials for biomedical applications • Functional materials • Hybrid and composite materials • Soft materials • Hydrogels • Nanomaterials • Gene delivery • Nonodevices • Metamaterials • Active coatings • Surface functionalization • Tissue engineering • Cell delivery/cell encapsulation systems • 3D printing materials • Material characterization • Biomechanics
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