比较注射肉毒杆菌毒素 A 和局部注射糖皮质激素治疗喉接触性肉芽肿的效果

IF 2.5 4区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Journal of Voice Pub Date : 2025-05-01 DOI:10.1016/j.jvoice.2022.11.037

Yufei Pan , Jinrang Li , Zhi Liu , Chun Zhang , Lianlian Liu , Xiaoyu Wang , Jinhong Zhang

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引用次数: 0

摘要

目的比较A型肉毒毒素注射液和局部糖皮质激素注射液治疗喉接触性肉芽肿的效果，探讨两种方案的适应证：回顾性分析解放军总医院第六医学中心门诊2020年1月-2021年12月收治的50例喉接触性肉芽肿患者的病例资料，根据患者接受的不同治疗方法分为以下两组：A型肉毒毒素注射或局部糖皮质激素注射。使用 Image J 软件对病灶大小进行定量评估，比较两组患者的疗效：比较两组治疗后 3 个月的治愈率，肉毒毒素 A 组有 72% 的患者治愈，而糖皮质激素组只有 40% 的患者治愈（P = 0.023）。治疗6个月后，比较两组患者的治愈率，肉毒杆菌毒素A组有88%的患者治愈，而糖皮质激素组只有64%的患者治愈（P = 0.047）：肉毒杆菌毒素A注射优于局部糖皮质激素注射，局部糖皮质激素注射更适合不能耐受肉毒杆菌毒素A不良反应的患者。

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Comparison of the Effects of Botulinum Toxin A Injection and Local Glucocorticoid Injection for Treating Laryngeal Contact Granuloma

Objectives

To compare the effects of botulinum toxin A injection and local glucocorticoid injection for treating laryngeal contact granuloma and to discuss the indications for both regimens.

Methods

The case data of 50 patients with laryngeal contact granuloma in the outpatient clinic of the Sixth Medical Center of the PLA General Hospital from January 2020 to December 2021 were reviewed, and the patients were divided into the following two groups according to the different treatments received: botulinum toxin A injection or local glucocorticoid injection. Quantitative assessment of the lesion size was performed using Image J software to compare the efficacy in the two groups.

Results

On comparing the cure rate between the two groups at 3 months after treatment, 72% of patients in the botulinum toxin A group were cured compared to 40% of patients in the glucocorticoid group (P = 0.023). On comparing the cure rate between the two groups at 6 months after treatment, 88% of patients in the botulinum toxin A group were cured compared to 64% of patients in the glucocorticoid group (P = 0.047).

Conclusions

Botulinum toxin A injection is superior to local glucocorticoid injection, and local glucocorticoid injection is more appropriate for patients who cannot tolerate the adverse effects of botulinum toxin A.

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来源期刊

Journal of Voice 医学-耳鼻喉科学

CiteScore

4.00

自引率

13.60%

发文量

395

审稿时长

59 days

期刊介绍： The Journal of Voice is widely regarded as the world''s premiere journal for voice medicine and research. This peer-reviewed publication is listed in Index Medicus and is indexed by the Institute for Scientific Information. The journal contains articles written by experts throughout the world on all topics in voice sciences, voice medicine and surgery, and speech-language pathologists'' management of voice-related problems. The journal includes clinical articles, clinical research, and laboratory research. Members of the Foundation receive the journal as a benefit of membership.