M R Pérez-Torres Lobato, M Molina Mata, M L Llempen López, I Fernández-Pineda, R M Cabello Laureano, J Rodríguez Martorell
{"title":"血栓弹性测量引导下神经母细胞瘤合并弥散性血管内凝血的手术治疗。","authors":"M R Pérez-Torres Lobato, M Molina Mata, M L Llempen López, I Fernández-Pineda, R M Cabello Laureano, J Rodríguez Martorell","doi":"10.54847/cp.2023.01.20","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Disseminated intravascular coagulation (DIC) is a rare oncological emergency. We report a pediatric neuroblastoma complicated with DIC which required thromboelastometry-guided surgery.</p><p><strong>Observation: </strong>A 6-year-old female diagnosed with intermediate risk adrenal neuroblastoma developed tumor-related DIC after chemotherapy first cycle. She remained stable without clinical bleeding and emergent tumor resection guided by intraoperative-thromboelastometry was decided. DIC resolved early after surgery and complete remission was achieved.</p><p><strong>Conclusion: </strong>Treatment of the underlying condition is critical to manage DIC. Thromboelastometry can guide goal-directed therapy, including surgery in pediatric patients. However, larger studies are needed to examine its applicability in different clinical settings, such as cancer related DIC.</p>","PeriodicalId":10316,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"36 1","pages":"44-47"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Thromboelastometry-guided surgery in neuroblastoma complicated with disseminated intravascular coagulation.\",\"authors\":\"M R Pérez-Torres Lobato, M Molina Mata, M L Llempen López, I Fernández-Pineda, R M Cabello Laureano, J Rodríguez Martorell\",\"doi\":\"10.54847/cp.2023.01.20\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Disseminated intravascular coagulation (DIC) is a rare oncological emergency. We report a pediatric neuroblastoma complicated with DIC which required thromboelastometry-guided surgery.</p><p><strong>Observation: </strong>A 6-year-old female diagnosed with intermediate risk adrenal neuroblastoma developed tumor-related DIC after chemotherapy first cycle. She remained stable without clinical bleeding and emergent tumor resection guided by intraoperative-thromboelastometry was decided. DIC resolved early after surgery and complete remission was achieved.</p><p><strong>Conclusion: </strong>Treatment of the underlying condition is critical to manage DIC. Thromboelastometry can guide goal-directed therapy, including surgery in pediatric patients. However, larger studies are needed to examine its applicability in different clinical settings, such as cancer related DIC.</p>\",\"PeriodicalId\":10316,\"journal\":{\"name\":\"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica\",\"volume\":\"36 1\",\"pages\":\"44-47\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.54847/cp.2023.01.20\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54847/cp.2023.01.20","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Thromboelastometry-guided surgery in neuroblastoma complicated with disseminated intravascular coagulation.
Background: Disseminated intravascular coagulation (DIC) is a rare oncological emergency. We report a pediatric neuroblastoma complicated with DIC which required thromboelastometry-guided surgery.
Observation: A 6-year-old female diagnosed with intermediate risk adrenal neuroblastoma developed tumor-related DIC after chemotherapy first cycle. She remained stable without clinical bleeding and emergent tumor resection guided by intraoperative-thromboelastometry was decided. DIC resolved early after surgery and complete remission was achieved.
Conclusion: Treatment of the underlying condition is critical to manage DIC. Thromboelastometry can guide goal-directed therapy, including surgery in pediatric patients. However, larger studies are needed to examine its applicability in different clinical settings, such as cancer related DIC.
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