一株引起菌血症的耐利奈唑胺头炎葡萄球菌的基因组分析:来自意大利中部一所大学医院的报告。

IF 2.3 4区医学 Q3 INFECTIOUS DISEASES

Microbial drug resistance Pub Date : 2023-09-01 DOI:10.1089/mdr.2022.0330

Lucia Brescini, Simona Fioriti, Sonia N Coccitto, Marzia Cinthi, Marina Mingoia, Oscar Cirioni, Andrea Giacometti, Eleonora Giovanetti, Gianluca Morroni, Andrea Brenciani

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引用次数: 0

摘要

虽然凝固酶阴性葡萄球菌很少与复杂疾病相关，但在某些情况下，它们会导致危及生命的感染。在这里，我们描述了一个临床病例的细菌血症由于甲氧西林和利奈唑胺耐药头皮炎葡萄球菌在一个病人以前接受过利奈唑胺治疗。全基因组测序结果显示，所有rDNA 23S等位基因均存在共同突变G2576T，并存在多个获得性耐药基因。此外，该分离株在流行病学上与通常导致新生儿重症监护病房院内感染的NRCS-A分支相距遥远。我们的研究结果进一步证实了小葡萄球菌获得抗生素耐药性的能力，并对这些感染的治疗提出了挑战。

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Genomic Analysis of a Linezolid-Resistant Staphylococcus capitis Causing Bacteremia: Report from a University Hospital in Central Italy.

Although coagulase negative staphylococci are rarely associated with complicated diseases, in some cases they cause life-threatening infections. Here we described a clinical case of a bacteremia due to a methicillin- and linezolid-resistant Staphylococcus capitis in a patient previously treated with linezolid. Whole genome sequencing revealed the common mutation G2576T in all rDNA 23S alleles and several acquired resistance genes. Moreover, the isolate was epidemiologically distant from the NRCS-A clade, usually responsible for nosocomial infections in neonatal intensive care units. Our findings further confirm the ability of minor staphylococci to acquire antibiotic resistances and challenge the treatment of these infections.

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来源期刊

Microbial drug resistance 医学-传染病学

CiteScore

6.00

自引率

3.80%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Microbial Drug Resistance (MDR) is an international, peer-reviewed journal that covers the global spread and threat of multi-drug resistant clones of major pathogens that are widely documented in hospitals and the scientific community. The Journal addresses the serious challenges of trying to decipher the molecular mechanisms of drug resistance. MDR provides a multidisciplinary forum for peer-reviewed original publications as well as topical reviews and special reports. MDR coverage includes: Molecular biology of resistance mechanisms Virulence genes and disease Molecular epidemiology Drug design Infection control.