从单克隆抗体1F7的研究中我们可以学到什么?

Q3 Medicine

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Pub Date : 2022-12-01 DOI:10.1089/mab.2022.0003

Heinz Kohler

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引用次数: 0

摘要

1F7是一种单克隆抗体，可识别结合HIV-1和丙型肝炎蛋白的灵长类抗体上表达的独特型决定因子。该单克隆抗体被用作分析人类感染HIV-1和乙型肝炎的免疫应答的工具。此外，1F7也被用于操纵猕猴对HIV-1的免疫应答。描述网络的单克隆抗体的产生表明，类似的抗体可以开发为解剖自身免疫性疾病和过敏反应中纠缠网络的工具。这篇综述讨论了在当代免疫学的基础上用1F7所做的工作。

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What Can We Learn from Research with Monoclonal Antibody 1F7?

1F7 is a monoclonal antibody that recognizes an idiotypic determinant expressed on primate antibodies binding to HIV-1 and hepatitis C proteins. This monoclonal antibody was used as a tool to dissect the immune response in humans infected with HIV-1 and hepatitis B. Furthermore, 1F7 was also used to manipulate the immune response against HIV-1 in macaques. The generation of a monoclonal antibody describing a network suggests similar antibodies could be developed as tools to dissect entangled networks in autoimmune diseases and allergic reactions. This review discusses the body of work done with 1F7 in the light of contemporary immunology.

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来源期刊

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Medicine-Immunology and Allergy

CiteScore

4.80

自引率

0.00%

发文量