在喂食标准或肥胖促进饮食的大鼠中,Bimatoprost促进饱腹感并减轻体重增加。

IF 3
Clayton Spada , Chau Vu , Iona Raymond , Warren Tong , Chia-Lin Chuang , Christopher Walker , Kerry Loomes , David F. Woodward , Neil J. Poloso
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引用次数: 1

摘要

比马前列素是一种合成的前列腺素F2α类似物,在体外下调脂肪生成。这种效应归因于参与调节阿南达胺诱导的脂肪形成的负反馈回路。一项后续的研究现在已经在正常状态和肥胖诱导条件下对比马前列素的更广泛的代谢作用进行了研究。在9-10周的时间内,给予慢性比马前列素以剂量依赖性的方式减轻了喂食标准[最大效应- 7%]或促进肥胖饮食[最大效应- 23%]的大鼠的体重增加。与这些发现一致,bimatoprost通过减少食物摄入量(最大效应,- 7%)、胃排空(最大效应,- 33-50%)和降低肠道激素、胃促生长素和GLP-1的循环浓度(最大效应,- 33-50%)来促进饱腹感。此外,皮下和内脏脂肪量明显受到治疗的影响[- 30%不依赖饮食]。综上所述,这些结果表明,bimatoprost通过促进饱腹感和减少食物摄入来调节能量稳态。这些新报道的比马前列素的活性揭示了代谢疾病干预的潜在治疗开发的另一种方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bimatoprost promotes satiety and attenuates body weight gain in rats fed standard or obesity-promoting diets.

Bimatoprost is a synthetic prostamide F analog that down-regulates adipogenesis in vitro. This effect has been attributed to participation in a negative feedback loop that regulates anandamide-induced adipogenesis. A follow-on investigation has now been conducted into the broader metabolic effects of bimatoprost using rats under both normal state and obesity-inducing conditions. Chronic bimatoprost administration attenuated weight gain in a dose dependent-manner in rats fed either standard [max effect −7%] or obesity-promoting diets [max effect −23%] over a 9–10 week period. Consistent with these findings, bimatoprost promoted satiety as measured by decreased food intake [max effect, −7%], gastric emptying [max effect, −33–50%] and decreased circulating concentrations of the gut hormones, ghrelin and GLP-1 [max effect, −33–50%]. Additionally, subcutaneous, and visceral fat mass were distinctly affected by treatment [−30% diet independent]. Taken together, these results suggest that bimatoprost regulates energy homeostasis through promoting satiety and a decrease in food intake. These newly reported activities of bimatoprost reveal an additional method of metabolic disease intervention for potential therapeutic exploitation.

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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
自引率
0.00%
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审稿时长
64 days
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