围产期日粮中α-亚麻酸富集对低密度脂蛋白受体敲除(LDLRKO)小鼠成年后代高脂饮食诱导的SCD1活性升高和脂质紊乱的影响

IF 3
A. Leikin-Frenkel , H. Cohen , R. Keshet , R. Shnerb-GanOr , M. Kandel-Kfir , A. Harari , K.S. Hollander , A. Shaish , D. Harats , Y. Kamari
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引用次数: 1

摘要

本研究探讨了母体围产期饮食ALA富集对低密度脂蛋白受体敲除(LDLRKO)小鼠成年后代高脂肪饮食(HFD)诱导的脂质紊乱的影响。雌性LDLRKO小鼠在怀孕和哺乳期间接受含有玉米油(RD)或亚麻油(ALA)的等热量饮食。断奶后的幼崽在8周的洗脱期给予正常的食物饮食,随后给予8周的HFD。然后分析血浆和肝脏脂质以及SCD1活性。饲喂hfd的RD成年后代血浆胆固醇水平明显高于饲喂hfd的ALA后代(15.7对9.7 mmol /l, p<0.00001)和非酒精性脂肪性肝病(NAFLD)(65.0对23.9 mg/g脂质,p<0.00001)。与ALA相比,RD的肝脂质油酸(OA)含量和单不饱和脂肪酸/饱和脂肪酸(MUFA/SAT)比低2倍(p<0.0001)。hfd诱导的SCD1活性增加了三倍(p<0.00001),并且在RD成年后代中观察到SA产生的OA被围产期ALA阻止。综上所述,SCD1对HFD诱导的活性增加的恢复能力可能解释了围产期饮食中富集ALA对预防成年LDLRKO后代小鼠NAFLD和高胆固醇血症的有益作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of α-linolenic acid enrichment in perinatal diets in preventing high fat diet-induced SCD1 increased activity and lipid disarray in adult offspring of low density lipoprotein receptor knockout (LDLRKO) mice

The present study examined the effects of maternal perinatal dietary ALA enrichment on the high fat diet (HFD)-induced lipid disarray in the adult offspring of low density lipoprotein receptor knock-out (LDLRKO) mice.

Female LDLRKO mice received, during pregnancy and lactation, isocaloric diets with either corn oil, RD, or flax oil, ALA. The weaning offspring was given a regular chow diet for a washout period of eight weeks, which was followed by HFD for eight weeks. Plasma and liver lipids and SCD1 activity were then analyzed.

The HFD-fed RD adult offspring had substantially higher plasma cholesterol levels than the HFD-fed ALA offspring (15.7 versus 9.7 mmole/l, p<0.00001) and non-alcoholic fatty liver disease (NAFLD) (65.0 versus 23.9 mg/g lipids, p<0.00001). Liver lipids oleic acid (OA) content and monounsaturated to saturated fatty acids (MUFA/SAT) ratio, were two times lower in RD compared to ALA (p<0.0001). The threefold HFD-induced SCD1 raised activity (p<0.00001), and OA produced from SA, observed in RD adult offspring were prevented by perinatal ALA.

In conclusion, the resilience of SCD1 to HFD- induced increased activity may account for the beneficial effects of perinatal ALA dietary enrichment in preventing NAFLD and hypercholesterolemia from occurring in adult LDLRKO offspring mice.

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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
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审稿时长
64 days
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