Covid-19疫苗和神经系统并发症:系统综述

IF 1.8 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Fakhri Allahyari, Hamideh Molaee, Javad Hosseini Nejad
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引用次数: 5

摘要

COVID-19主要引起呼吸道疾病,感染率高,发病率和死亡率高。神经科医生对潜在的神经系统副作用、利润和COVID-19疫苗的时机表示担忧。本研究旨在对COVID-19疫苗与神经系统并发症的研究进行系统回顾。数据检索于Scopus、ISI web of knowledge、Medline、PubMed、Wiley、Embase、International Clinical Trials Registry Platform and Clinical Trials、Cochrane Library和Google Scholar。两位审稿人分别检索和评估了所有文章的标题和摘要。第三位审稿人解决了他们之间的分歧。记录了有关研究地点、研究设计、并发症类型、患者数量、各种类型的COVID-19疫苗和神经系统并发症类型的数据。新冠病毒疫苗与神经系统并发症的6项研究,包括2项mRNA疫苗后神经系统表现的研究,4项载体疫苗副作用的研究。与mRNA疫苗相关的主要神经系统并发症是身体疼痛、感觉异常、行走困难、红斑移动性病变、疲劳、肌痛和左外侧三角肌区疼痛。与载体疫苗相关的主要神经系统并发症是尿潴留困难、进食和走动、手臂酸痛、轻度疲劳、寒战、左侧面部下垂、头痛、全身性癫痫发作、偏盲和轻度失语、急性嗜睡和右手偏瘫、急性横贯脊髓炎、左腿深静脉血栓形成、警觉性障碍和抽搐、严重的固定性斜阵肌阵挛综合征和脑炎。大量的严重神经系统疾病已被报道。这些并发症可能是分子刺激和后来的神经元损伤的结果。一般而言,在个体和人群水平上,COVID-19疫苗接种的优势在神经系统并发症的风险方面占主导地位。未来的调查将需要发现神经系统并发症与COVID-19疫苗之间的任何关系,主要是因为新的病毒株和针对它们的新疫苗在技术上很先进。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Covid-19 vaccines and neurological complications: a systematic review.

The COVID-19 mainly causes respiratory disorders with high infection and severe morbidity and mortality. Neurologists have concerns about potential neurological side effects, profits, and timing of COVID-19 vaccines. This study aimed to review systematically research for the COVID-19 vaccine and neurological complications. Data was searched in Scopus, ISI web of knowledge, Medline, PubMed, Wiley, Embase, International Clinical Trials Registry Platform and Clinical Trials, Cochrane Library, and Google Scholar. Two reviewer authors individually searched and assessed the titles and abstracts of all articles. The third reviewer resolved disagreement between them. Data were documented regarding study location, study design, type of complications, number of patients, various types of COVID-19 vaccine, and type of neurological complications. Six studies in COVID-19 vaccine and neurological complications include two studies about neurological manifestations after the mRNA vaccines, four records about side effects of vector-based vaccine were included in the study. The main neurological complication associated mRNA vaccines were body aches, paresthesia, and difficulty walking, erythema migrans lesion, fatigue, myalgia, and pain in the left lateral deltoid region. The major neurological complication related to vector-based vaccines were urinary retention difficulty, feeding and ambulating, arm soreness, mild fatigue, chills, left-sided facial droop, headaches, a generalized epileptic seizure, hemianopia, and mild aphasia, acute somnolence and right-hand hemiparesis, acute transverse myelitis, deep vein thrombosis in her left leg, a vigilance disorder and a twitching, a severe immobilizing opsoclonus myoclonus syndrome, and encephalitis. A large spectrum of severe neurological unfavorable has been reported. These complications could occur as a result of molecular stimulation and later neuronal damage. Generally, the advantages of COVID-19 vaccination are dominant on the risks of a neurological complication at both individual and population levels. Future investigations will be required to find any relationship between neurological complications and COVID-19 vaccines principally as new strains of the virus and new vaccines are technologically advanced against them.

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来源期刊
CiteScore
4.10
自引率
5.00%
发文量
55
期刊介绍: A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products. The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products. A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.
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