胡萝卜引起的食物依赖性运动致过敏反应1例报告。

IF 1.1 4区医学 Q4 ALLERGY

Pediatric Allergy Immunology and Pulmonology Pub Date : 2022-12-01 DOI:10.1089/ped.2022.0122

Nami Hirai, Mika Ogata, Jun Kido, Masashi Nakamura, Nayu Sato, Nobue Takamatsu, Naoshi Shimojo, Yuji Aoki, Kayoko Matsunaga, Tomoyuki Mizukami

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引用次数: 1

摘要

背景:大多数食物依赖性运动诱发过敏性反应(FDEIA)病例是由食用小麦或甲壳类动物引起的。然而，水果或蔬菜很少会成为FDEIA的过敏原。我们报告一例罕见的由吃胡萝卜引起的FDEIA。病例介绍:一名8岁男孩在吃了含有煮熟胡萝卜的午餐后，在玩耍时发生过敏反应。血清胡萝卜特异性免疫球蛋白E水平为0.19 UA/mL。生胡萝卜的逐刺试验呈阳性(轮径:4mm)。患者在食用生胡萝卜后进行运动激发试验后出现荨麻疹。采用二维免疫印迹法分析胡萝卜蛋白，鉴定致敏原。9个蛋白在21-66 kDa处被鉴定为候选抗原。结论:本例患者在食用生胡萝卜和熟胡萝卜后均出现了FDEIA症状。生的和煮熟的胡萝卜都含有9种可能诱发FDEIA的蛋白质。

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Food-Dependent Exercise-Induced Anaphylaxis Caused by Carrots: A Case Report.

Background: Most cases of food-dependent exercise-induced anaphylaxis (FDEIA) are caused by eating wheat or crustaceans. However, fruits or vegetables may rarely act as allergens for FDEIA. We report a rare case of FDEIA caused by eating carrots. Case Presentation: An 8-year-old boy developed an anaphylactic reaction while playing, after eating lunch that included cooked carrots. Serum carrot-specific immunoglobulin E level was 0.19 UA/mL. The prick-by-prick test for raw carrots was positive (wheal diameter: 4 mm). The patient developed urticaria after exercise provocation tests following ingestion of raw carrots. Carrot proteins were analyzed by 2-dimensional Western blotting to identify the causative allergens. Nine proteins were identified as candidate antigens at 21-66 kDa. Conclusions: Our patient presented with FDEIA symptoms after ingesting both raw and cooked carrots. Both raw and cooked carrots contain 9 proteins that may induce FDEIA.

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来源期刊

Pediatric Allergy Immunology and Pulmonology ALLERGY-IMMUNOLOGY

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pediatric Allergy, Immunology, and Pulmonology is a peer-reviewed journal designed to promote understanding and advance the treatment of respiratory, allergic, and immunologic diseases in children. The Journal delivers original translational, clinical, and epidemiologic research on the most common chronic illnesses of children—asthma and allergies—as well as many less common and rare diseases. It emphasizes the developmental implications of the morphological, physiological, pharmacological, and sociological components of these problems, as well as the impact of disease processes on families. Pediatric Allergy, Immunology, and Pulmonology coverage includes: -Functional and genetic immune deficiencies- Interstitial lung diseases- Both common and rare respiratory, allergic, and immunologic diseases- Patient care- Patient education research- Public health policy- International health studies