Ibrahim Toprak, Francisco Cavas, José S Velázquez, Jorge L Alio Del Barrio, Jorge L Alio
{"title":"唐氏综合征角膜病变与圆锥角膜的三维形态-体积相似性研究。","authors":"Ibrahim Toprak, Francisco Cavas, José S Velázquez, Jorge L Alio Del Barrio, Jorge L Alio","doi":"10.1186/s40662-022-00315-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>To compare and contrast morpho-volumetric features between Down syndrome (DS) cornea and non-DS keratoconic cornea by three-dimensional (3D) modelling.</p><p><strong>Methods: </strong>Forty-three subjects (43 eyes) with DS and 99 patients matching their age and sex (99 eyes) with keratoconus (KC) were included in this single-center cross-sectional study. Main outcome measures were high-order aberrations (HOA), central corneal thickness (CCT), spherical equivalent refraction, and morpho-volumetric parameters established using a 3D corneal model, such as deviation of anterior and posterior corneal apices (D<sub>apexant</sub>/D<sub>apexpost</sub>) and minimum thickness points (D<sub>mctant</sub>/D<sub>mctpost</sub>) from corneal vertex, areas of the anterior and posterior surfaces (A<sub>ant</sub>/A<sub>post</sub>), sagittal area passing through the anterior and posterior corneal apices (A<sub>apexant</sub>/A<sub>apexpost</sub>) and minimum thickness point (A<sub>mctpost</sub>) and corneal volume of the complete cornea (V<sub>total</sub>).</p><p><strong>Results: </strong>Age, gender, spherical equivalent refraction, CCT and V<sub>total</sub> were similar between the net on-DS KC and DS groups (P > 0.05), while non-DS KC group had higher HOA than the DS group (P < 0.05). D<sub>apexant</sub>, A<sub>ant</sub>, A<sub>post</sub> and A<sub>apexant</sub> showed higher values in the DS group than in the non-DS KC group, whereas D<sub>apexpost</sub> showed a reduction in the DS group when compared with the non-DS KC group (P < 0.05).</p><p><strong>Conclusions: </strong>This study demonstrated that anterior and posterior corneal apex dynamics were specifically different in DS subjects, as the anterior apex tends to displace more prominently when compared to that from the non-DS KC group, while the posterior apex appears to be more stable than that in non-DS KC, which also support the theory that DS patients suffer from a specific keratopathy, distinctively different to KC but strongly related to it, and probably showing a diversity of corneal phenotypes in all cases of DS.</p>","PeriodicalId":12194,"journal":{"name":"Eye and Vision","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809058/pdf/","citationCount":"0","resultStr":"{\"title\":\"A three-dimensional morpho-volumetric similarity study of Down syndrome keratopathy vs. keratoconus.\",\"authors\":\"Ibrahim Toprak, Francisco Cavas, José S Velázquez, Jorge L Alio Del Barrio, Jorge L Alio\",\"doi\":\"10.1186/s40662-022-00315-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>To compare and contrast morpho-volumetric features between Down syndrome (DS) cornea and non-DS keratoconic cornea by three-dimensional (3D) modelling.</p><p><strong>Methods: </strong>Forty-three subjects (43 eyes) with DS and 99 patients matching their age and sex (99 eyes) with keratoconus (KC) were included in this single-center cross-sectional study. Main outcome measures were high-order aberrations (HOA), central corneal thickness (CCT), spherical equivalent refraction, and morpho-volumetric parameters established using a 3D corneal model, such as deviation of anterior and posterior corneal apices (D<sub>apexant</sub>/D<sub>apexpost</sub>) and minimum thickness points (D<sub>mctant</sub>/D<sub>mctpost</sub>) from corneal vertex, areas of the anterior and posterior surfaces (A<sub>ant</sub>/A<sub>post</sub>), sagittal area passing through the anterior and posterior corneal apices (A<sub>apexant</sub>/A<sub>apexpost</sub>) and minimum thickness point (A<sub>mctpost</sub>) and corneal volume of the complete cornea (V<sub>total</sub>).</p><p><strong>Results: </strong>Age, gender, spherical equivalent refraction, CCT and V<sub>total</sub> were similar between the net on-DS KC and DS groups (P > 0.05), while non-DS KC group had higher HOA than the DS group (P < 0.05). D<sub>apexant</sub>, A<sub>ant</sub>, A<sub>post</sub> and A<sub>apexant</sub> showed higher values in the DS group than in the non-DS KC group, whereas D<sub>apexpost</sub> showed a reduction in the DS group when compared with the non-DS KC group (P < 0.05).</p><p><strong>Conclusions: </strong>This study demonstrated that anterior and posterior corneal apex dynamics were specifically different in DS subjects, as the anterior apex tends to displace more prominently when compared to that from the non-DS KC group, while the posterior apex appears to be more stable than that in non-DS KC, which also support the theory that DS patients suffer from a specific keratopathy, distinctively different to KC but strongly related to it, and probably showing a diversity of corneal phenotypes in all cases of DS.</p>\",\"PeriodicalId\":12194,\"journal\":{\"name\":\"Eye and Vision\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2023-01-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809058/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Eye and Vision\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s40662-022-00315-0\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eye and Vision","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40662-022-00315-0","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
A three-dimensional morpho-volumetric similarity study of Down syndrome keratopathy vs. keratoconus.
Background: To compare and contrast morpho-volumetric features between Down syndrome (DS) cornea and non-DS keratoconic cornea by three-dimensional (3D) modelling.
Methods: Forty-three subjects (43 eyes) with DS and 99 patients matching their age and sex (99 eyes) with keratoconus (KC) were included in this single-center cross-sectional study. Main outcome measures were high-order aberrations (HOA), central corneal thickness (CCT), spherical equivalent refraction, and morpho-volumetric parameters established using a 3D corneal model, such as deviation of anterior and posterior corneal apices (Dapexant/Dapexpost) and minimum thickness points (Dmctant/Dmctpost) from corneal vertex, areas of the anterior and posterior surfaces (Aant/Apost), sagittal area passing through the anterior and posterior corneal apices (Aapexant/Aapexpost) and minimum thickness point (Amctpost) and corneal volume of the complete cornea (Vtotal).
Results: Age, gender, spherical equivalent refraction, CCT and Vtotal were similar between the net on-DS KC and DS groups (P > 0.05), while non-DS KC group had higher HOA than the DS group (P < 0.05). Dapexant, Aant, Apost and Aapexant showed higher values in the DS group than in the non-DS KC group, whereas Dapexpost showed a reduction in the DS group when compared with the non-DS KC group (P < 0.05).
Conclusions: This study demonstrated that anterior and posterior corneal apex dynamics were specifically different in DS subjects, as the anterior apex tends to displace more prominently when compared to that from the non-DS KC group, while the posterior apex appears to be more stable than that in non-DS KC, which also support the theory that DS patients suffer from a specific keratopathy, distinctively different to KC but strongly related to it, and probably showing a diversity of corneal phenotypes in all cases of DS.
期刊介绍:
Eye and Vision is an open access, peer-reviewed journal for ophthalmologists and visual science specialists. It welcomes research articles, reviews, methodologies, commentaries, case reports, perspectives and short reports encompassing all aspects of eye and vision. Topics of interest include but are not limited to: current developments of theoretical, experimental and clinical investigations in ophthalmology, optometry and vision science which focus on novel and high-impact findings on central issues pertaining to biology, pathophysiology and etiology of eye diseases as well as advances in diagnostic techniques, surgical treatment, instrument updates, the latest drug findings, results of clinical trials and research findings. It aims to provide ophthalmologists and visual science specialists with the latest developments in theoretical, experimental and clinical investigations in eye and vision.