第五次中枢神经系统世界卫生组织分类中的儿童型弥漫性高级别胶质瘤。

IF 4.4 Q1 PATHOLOGY
PATHOLOGICA Pub Date : 2022-12-01 DOI:10.32074/1591-951X-830
Francesca Gianno, Isabella Giovannoni, Barbara Cafferata, Francesca Diomedi-Camassei, Simone Minasi, Sabina Barresi, Francesca Romana Buttarelli, Viola Alesi, Antonello Cardoni, Manila Antonelli, Chiara Puggioni, Giovanna Stefania Colafati, Andrea Carai, Maria Vinci, Angela Mastronuzzi, Evelina Miele, Rita Alaggio, Felice Giangaspero, Sabrina Rossi
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引用次数: 0

摘要

中枢神经系统世界卫生组织第五次分类的一个新颖之处在于,它首次承认了儿科型弥漫性胶质瘤家族(包括高级别和低级别),从而突出了主要发生于儿童的胶质瘤的独特病理生物学基础。本综述将重点讨论儿科型弥漫性高级别胶质瘤家族,其中包括四种肿瘤类型:1)弥漫性中线胶质瘤 H3 K27-变异型;2)弥漫性半球胶质瘤 H3 G34-突变型;3)弥漫性儿科型高级别胶质瘤 H3-野生型和 IDH-野生型;以及 4)婴儿型半球胶质瘤。将讨论每种肿瘤类型的基本和理想诊断标准以及鉴别中的实体。将特别关注在日常实践中遇到的问题,尤其是关于弥漫性儿科型高级别胶质瘤 H3-野生型和 IDH-野生型的诊断。在每种诊断情况下,将评估可用于定义该肿瘤家族实体的多种分子检测的优势和局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification.

Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification.

Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification.

Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification.

As a relevant element of novelty, the fifth CNS WHO Classification highlights the distinctive pathobiology underlying gliomas arising primarily in children by recognizing for the first time the families of paediatric-type diffuse gliomas, both high-grade and low-grade. This review will focus on the family of paediatric-type diffuse high-grade gliomas, which includes four tumour types: 1) Diffuse midline glioma H3 K27-altered; 2) Diffuse hemispheric glioma H3 G34-mutant; 3) Diffuse paediatric-type high-grade glioma H3-wildtype and IDH-wildtype; and 4) Infant-type hemispheric glioma. The essential and desirable diagnostic criteria as well as the entities entering in the differential will be discussed for each tumour type. A special focus will be given on the issues encountered in the daily practice, especially regarding the diagnosis of the diffuse paediatric-type high-grade glioma H3-wildtype and IDH-wildtype. The advantages and the limits of the multiple molecular tests which may be utilised to define the entities of this tumour family will be evaluated in each diagnostic context.

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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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