2021年WHO新分类中的成人型弥漫性胶质瘤

IF 4.4 Q1 PATHOLOGY
PATHOLOGICA Pub Date : 2022-12-01 DOI:10.32074/1591-951X-823
Manila Antonelli, Pietro Luigi Poliani
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引用次数: 6

摘要

成人型弥漫性胶质瘤是一组高度浸润的中枢神经系统肿瘤,其预后因具体亚型和组织学分级而有显著差异。传统上,成人型弥漫性胶质瘤是根据其形态学特征进行分类的,即使在相同的组织学分级内,观察者之间也存在很大的可变性和患者生存率的差异。在过去的几十年里,分子谱的进步极大地改变了脑肿瘤的诊断方法和分类,导致了一种综合形态学和分子分类的发展,赋予了更多的临床相关价值。这些概念在2016年出版的修订后的世卫组织中枢神经系统肿瘤分类第四版中得到了很大的预测。第五版(世卫组织2021年)将分子诊断向前推进,将分子参数与组织学特征完全整合为一种综合诊断方法。通过引入修订的诊断和分级标准,简化了成人型弥漫性胶质瘤、IDH突变型和IDH野生型的诊断。在这篇综述中,我们将讨论成人型弥漫性胶质瘤分类的最新进展,并总结必要的诊断关键,为病理学家提供实用指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Adult type diffuse gliomas in the new 2021 WHO Classification.

Adult type diffuse gliomas in the new 2021 WHO Classification.

Adult type diffuse gliomas in the new 2021 WHO Classification.

Adult type diffuse gliomas in the new 2021 WHO Classification.

Adult-type diffuse gliomas represent a group of highly infiltrative central nervous system tumors with a prognosis that significantly varies depending on the specific subtype and histological grade. Traditionally, adult-type diffuse gliomas have been classified based on their morphological features with a great interobserver variability and discrepancy in patient survival even within the same histological grade. Over the last few decades, advances in molecular profiling have drastically changed the diagnostic approach and classification of brain tumors leading to the development of an integrated morphological and molecular classification endowed with a more clinically relevant value. These concepts were largely anticipated in the revised fourth-edition of WHO classification of central nervous system tumors published in 2016. The fifth-edition (WHO 2021) moved molecular diagnostics forward into a full integration of molecular parameters with the histological features into an integrative diagnostic approach. Diagnosis of adult type diffuse gliomas, IDH mutant and IDH-wildtype has been simplified by introducing revised diagnostic and grading criteria. In this review, we will discuss the most recent updates to the classification of adult-type diffuse gliomas and summarize the essential diagnostic keys providing a practical guidance to pathologists.

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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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