巴西患者对青光眼药物治疗依从性的展望。

IF 3.1 Q2 PHARMACOLOGY & PHARMACY
Pharmaceutical Medicine Pub Date : 2023-09-01 Epub Date: 2023-06-08 DOI:10.1007/s40290-023-00482-y
Julia da Costa Andrade, Guilherme Samomiya Motta, Niro Kasahara
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引用次数: 0

摘要

背景:对青光眼药物治疗方案的依从性差可能与随后的视神经损伤和不可逆转的视力丧失有关。中低收入国家患者有效依从性的具体障碍尚未得到充分认识,已经开发出新的疾病特异性工具来评估依从性。目的:本横断面研究的目的是评估中等收入国家原发性开角型青光眼(POAG)患者对治疗的依从性。方法:POAG患者来自巴西圣保罗的青光眼服务机构Irmanade da Santa Casa de Misericordia。从参与者的电子记录中检索临床和人口统计数据。所有患者均接受了青光眼治疗依从性评估工具(GTCAT)。这份27项问卷旨在评估与青光眼药物依从性相关的多种行为因素。结果:样本包括96例POAG患者。平均年龄63.2±8.9岁;男48例,女48例;55人(57.3%)是白人,36人(37.5%)是非裔巴西人,5人(5.2%)是混合色。大多数患者(97.9%)的学历低于高中,并且都有家庭收入。结论:GTCAT在这一巴西患者队列中发现了许多与依从性相关的非故意因素。这些数据可能会影响如何理解和提高巴西人群对眼部降压治疗的依从性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Perspectives on Adherence to Glaucoma Medical Therapy in Brazilian Patients.

Background: Poor adherence to glaucoma medication regimens may be associated with subsequent optic nerve damage and irreversible visual loss. Specific barriers to effective patient adherence in low-middle income countries are not fully recognized and new disease-specific instruments to assess adherence have been developed.

Objective: The purpose of this cross-sectional study was to evaluate adherence of primary open-angle glaucoma (POAG) patients to treatment in a middle-income country.

Methods: POAG patients were recruited from the Glaucoma Service - Irmandade da Santa Casa de Misericordia de Sao Paulo, Sao Paulo, Brazil. Clinical and demographic data were retrieved from participants' electronic records. All patients answered the Glaucoma Treatment Compliance Assessment Tool (GTCAT). This 27-item questionnaire was designed to evaluate multiple behavioral factors associated with glaucoma medication adherence.

Results: The sample comprised 96 patients with POAG. The mean age was 63.2 ± 8.9 years; 48 were male and 48 female; 55 (57.3%) were White, 36 (37.5%) African-Brazilian, and five (5.2 %) were of mixed color. Most patients (97.9%) had less than a high school degree and all had a family income < US$10,000. The GTCAT identified 69 (71.8%) patients who "sometimes forget to use drops," 68 (70.8%) patients who "sometimes fall asleep before dosing time," and 60 (62.5%) patients "whose drops aren't with them at the time to take them"; 82 (85.4%) patients admitted to using "reminders to take medications." Eighty-two (85.4%) patients agreed that "doctor answers my questions," and 77 (80.5%) said "they are happy with their eye doctor."

Conclusions: The GTCAT identified a number of mostly unintentional factors associated with adherence in this cohort of Brazilian patients. The data may impact on how to understand and improve adherence to ocular hypotensive treatment in the Brazilian population.

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来源期刊
Pharmaceutical Medicine
Pharmaceutical Medicine PHARMACOLOGY & PHARMACY-
CiteScore
5.10
自引率
4.00%
发文量
36
期刊介绍: Pharmaceutical Medicine is a specialist discipline concerned with medical aspects of the discovery, development, evaluation, registration, regulation, monitoring, marketing, distribution and pricing of medicines, drug-device and drug-diagnostic combinations. The Journal disseminates information to support the community of professionals working in these highly inter-related functions. Key areas include translational medicine, clinical trial design, pharmacovigilance, clinical toxicology, drug regulation, clinical pharmacology, biostatistics and pharmacoeconomics. The Journal includes:Overviews of contentious or emerging issues.Comprehensive narrative reviews that provide an authoritative source of information on topical issues.Systematic reviews that collate empirical evidence to answer a specific research question, using explicit, systematic methods as outlined by PRISMA statement.Original research articles reporting the results of well-designed studies with a strong link to wider areas of clinical research.Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in Pharmaceutical Medicine may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.All manuscripts are subject to peer review by international experts. Letters to the Editor are welcomed and will be considered for publication.
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