肝脏疾病与 COVID-19:从病理生理学到治疗策略。

IF 2.7 4区 医学 Q2 Medicine
Canadian Journal of Gastroenterology and Hepatology Pub Date : 2022-12-08 eCollection Date: 2022-01-01 DOI:10.1155/2022/4291758
Parisa Shiri Aghbash, Hamed Ebrahimzadeh Leylabadlo, Hamidreza Fathi, Mohaddeseh Bahmani, Rojin Chegini, Hossein Bannazadeh Baghi
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引用次数: 0

摘要

继 SARS-CoV-2 爆发以及随后的 COVID-19 大流行发展之后,肺、肾、肝、心和脑等器官已被确定为优先器官。肝脏疾病被认为是 COVID-19 大流行导致高死亡率的一个风险因素。此外,相当一部分 COVID-19 患者,尤其是临床症状严重的患者,肝脏受损的情况已经得到证实。此外,抗病毒药物、肝移植后的免疫抑制药物、原有肝病和慢性肝病(如肝硬化)也与 SARS-CoV-2 引起的肝损伤有关。因此,人们采取了一些预防措施来预防、监测病毒,避免免疫力低下和易感人群(如肝脏和肾脏移植受者)感染 SARS-CoV-2,从而避免死亡率上升。本综述的目的是研究 SARS-CoV-2 感染造成的损害,以及大流行期间使用的药物对死亡率范围的影响,从而研究对肝病患者采取预防措施的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Hepatic Disorders and COVID-19: From Pathophysiology to Treatment Strategy.

Hepatic Disorders and COVID-19: From Pathophysiology to Treatment Strategy.

Following the SARS-CoV-2 outbreak and the subsequent development of the COVID-19 pandemic, organs such as the lungs, kidneys, liver, heart, and brain have been identified as priority organs. Liver diseases are considered a risk factor for high mortality from the COVID-19 pandemic. Besides, liver damage has been demonstrated in a substantial proportion of patients with COVID-19, especially those with severe clinical symptoms. Furthermore, antiviral medications, immunosuppressive drugs after liver transplantation, pre-existing hepatic diseases, and chronic liver diseases such as cirrhosis have also been implicated in SARS-CoV-2-induced liver injury. As a result, some precautions have been taken to prevent, monitor the virus, and avoid immunocompromised and susceptible individuals, such as liver and kidney transplant recipients, from being infected with SARS-CoV-2, thereby avoiding an increase in mortality. The purpose of this review was to examine the impairment caused by SARS-CoV-2 infection and the impact of drugs used during the pandemic on the mortality range and therefore the possibility of preventive measures in patients with liver disease.

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来源期刊
CiteScore
4.80
自引率
0.00%
发文量
0
审稿时长
37 weeks
期刊介绍: Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.
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