生物药品分类和生物药品处置系统在剂型开发中的新作用:系统综述。

IF 1.8 Q3 PHARMACOLOGY & PHARMACY
Ramu Samineni, Jithendra Chimakurthy, Sathish Konidala
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引用次数: 3

摘要

生物制药分类系统(BCS)是一种先进的分类工具,用于根据药物的溶出度、水溶性和肠通透性对药物进行分类,这些因素影响活性药物成分(API)从速释固体口服剂型的吸收。对于配方研究人员来说,基于现代方法而不是实验方法开发新剂型是有用的。本文主要综述了BCS的基本原理、目标、指导、BCS药物的特点、重要性和BCS的应用。这篇综述解释了药物开发中溶解度和体内处置方面的挑战。在本综述中,主要讨论了在药物开发和商业化的早期阶段用于改善BCS II药物溶解度和生物制药药物处置特性的新策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emerging Role of Biopharmaceutical Classification and Biopharmaceutical Drug Disposition System in Dosage form Development: A Systematic Review.

Biopharmaceutical classification system (BCS) is an advanced tool used for classifying medicines based on dissolution, water solubility, and intestinal permeability, which affect the absorption of active pharmaceutical ingredients (API) from immediate-release solid oral forms. It is useful to the formulation researchers to develop novel dosage forms based on modernistic rather than experimental approaches. The current review focuses on the fundamentals, objectives, guidance of BCS, characteristics of BCS drugs, their importance and applications of BCS. This review explains the challenges in drug development in terms of solubility and in vivo disposition. In the current review, new strategies for improving BCS II drug solubility as well as biopharmaceutical drug disposition properties which are utilized throughout the early stages of drug development and commercialization are mainly discussed.

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来源期刊
CiteScore
3.60
自引率
5.90%
发文量
79
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